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1. (WO1991007988) MEGAKARYOCYTE PRODUCTION
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/007988 International Application No.: PCT/US1990/006963
Publication Date: 13.06.1991 International Filing Date: 29.11.1990
IPC:
A61K 38/19 (2006.01) ,A61K 38/20 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
19
Cytokines; Lymphokines; Interferons
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
19
Cytokines; Lymphokines; Interferons
20
Interleukins
Applicants:
AMGEN INC. [US/US]; 1840 Dehavilland Drive Thousand Oaks, CA 91320-1789, US
Inventors:
YUNG, Yee, P.; US
WELTE, Karl; DE
Agent:
ODRE, Steven, M.; Amgen Inc. 1840 Dehavilland Drive Thousand Oaks, CA 91320, US
Priority Data:
444,88801.12.1989US
Title (EN) MEGAKARYOCYTE PRODUCTION
(FR) PRODUCTION DE MEGACARYOCYTES
Abstract:
(EN) A method of increasing megakaryocyte production is disclosed. Such method comprises administering to a mammal a pharmaceutically effective amount of G-CSF and a pharmaceutically effective amount of IL-3 or GM-CSF, and optionally a pharmaceutically effective amount of IL-6. Another method comprises administering GM-CSF and IL-5. Also disclosed are compositions for use in increasing megakaryocyte production. A method of increasing blood platelet production is also disclosed. Such method comprises administering to a mammal a pharmaceutically effective amount of IL-6 and optionally a pharmaceutically effective amount of IL-3, G-CSF or GM-CSF. Also disclosed are compositions for use in increasing blood platelet production.
(FR) Procédé d'augmentation de la production de mégacaryocytes. Ledit procédé consiste à administrer à un mammifère une dose pharmaceutiquement efficace de G-CSF et une dose pharmaceutiquement efficace de IL-3 ou de GM-CSF, et éventuellement une dose pharmaceutiquement efficace de IL-6. Une autre méthode consiste à administrer du GM-CSF et du IL-5. On décrit également les composés utilisés pour accroître la production de mégacaryocytes, ainsi qu'un procédé d'augmentation de la production des plaquettes sanguines. Ledit procédé consiste à administrer à un mammifère une dose pharmaceutiquement efficace de IL-6 et éventuellement une dose pharmaceutiquement efficace de IL-3, de G-CSF ou de GM-CSF. Sont également décrits des composés à utiliser pour augmenter la production de plaquettes sanguines.
Designated States: AU, FI, HU, JP, KR, NO, SU
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0456812PT96052KR1019920700693AU1991069673