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1. (WO1991007987) CHIMERIC ANTIBODY FOR DETECTION AND THERAPY OF INFECTIOUS AND INFLAMMATORY LESIONS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/007987 International Application No.: PCT/US1990/006972
Publication Date: 13.06.1991 International Filing Date: 04.12.1990
Chapter 2 Demand Filed: 10.06.1991
IPC:
A61K 47/48 (2006.01) ,A61K 49/16 (2006.01) ,A61K 51/10 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
06
Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
08
characterised by the carrier
10
Organic compounds
14
Peptides, e.g. proteins
16
Antibodies; Immunoglobulins; Fragments thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51
Preparations containing radioactive substances for use in therapy or testing in vivo
02
characterised by the carrier
04
Organic compounds
08
Peptides, e.g. proteins
10
Antibodies or immunoglobulins; Fragments thereof
Applicants:
IMMUNOMEDICS, INC. [US/US]; 150 Mount Bethel Road Warren, NJ 07060, US
Inventors:
GOLDENBERG, David, M.; US
HANSEN, Hans, J.; US
Agent:
SAXE, Bernhard, D. ; Foley and Lardner, Schwartz, Jeffery, Schwaab, Mack, Blumenthal & Evans 1800 Diagonal Road Alexandria, VA 22313, US
Priority Data:
446,54605.12.1989US
Title (EN) CHIMERIC ANTIBODY FOR DETECTION AND THERAPY OF INFECTIOUS AND INFLAMMATORY LESIONS
(FR) ANTICORPS CHIMERIQUE DE DETECTION ET DE TRAITEMENT DE LESIONS INFECTIEUSES ET INFLAMMATOIRES
Abstract:
(EN) A chimeric antibody-agent conjugate for targeting foci of leucocyte accretion comprises a recombinant chimera having an antigen-beinding hypervariable region which binds specifically to granulocytes, and a constant region of a human immunoglobulin having an Fc portion with high affinity for receptors on human mononuclear lymphoid cells, said chimera being conjugated to at least one diagnostic agent or therapeutic agent. A method for targeting an imaging or therapy agent to an inflammatory or infectious lesion comprises injecting a mammal parenterally with an effective amount for targeting of the above chimeric anti-leukocyte conjugate.
(FR) Un conjugué d'anticorps-agent chimériques permettant de cibler des foyers d'accrétion de leucocytes, comprend une chimère recombinée présentant une région hypervariable de liaison d'antigène, laquelle se lie spécifiquement à des granulocytes, ainsi qu'une région constante d'une immunoglobuline humaine ayant une partie Fc présentant une affinité élevée envers des récepteurs se trouvant sur des cellules lymphoïdes mononucléaires humaines, ladite chimère étant conjuguée à au moins un agent diagnostique ou un agent thérapeutique. Un procédé de ciblage d'un agent d'imagerie ou de thérapie sur une lésion inflammatoire ou infectieuse, consiste à injecter par voie parentérale à un mammifère une dose efficace permettant de cibler le conjugué anti-leucocyte chimérique précité.
Designated States: AU, BR, DK, FI, JP, KR, NO
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
IL96534CA2031129KR1019927003110AU1991071666