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1. (WO1991007985) MONOCLONAL ANTIBODY WHICH DISTINGUISHES HELPER INDUCER AND SUPRESSOR INDUCER CE4+ LYMPHOCYTES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/007985 International Application No.: PCT/US1990/006683
Publication Date: 13.06.1991 International Filing Date: 15.11.1990
Chapter 2 Demand Filed: 24.06.1991
IPC:
A61K 38/00 (2006.01) ,C07K 16/28 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
Applicants:
DANA-FARBER CANCER INSTITUTE [US/US]; 44 Binney Street Boston, MA 02115, US
Inventors:
SCHLOSSMAN, Stuart, F.; US
MORIMOTO, Chikao; US
Agent:
CASS, Myron, C. ; Silverman, Cass & Singer, Ltd. 105 West Adams Street 27th Floor Chicago, IL 60603, US
Priority Data:
442,06228.11.1989US
Title (EN) MONOCLONAL ANTIBODY WHICH DISTINGUISHES HELPER INDUCER AND SUPRESSOR INDUCER CE4+ LYMPHOCYTES
(FR) ANTICORPS MONOCLONAL POUVANT DIFFERENCIER ENTRE LES LYMPHOCYTES CD4+ INDUCTEURS D'ASSISTANTS ET INDUCTEURS DE SUPPRESSEURS
Abstract:
(EN) A monoclonal antibody which binds preferentially to a subset of the human CD4+ lymphocyte population whereby to positively and precisely distinguish between helper-inducer and supressor-inducer cells in the CD4+ cell population. The monoclonal antibody recognizes a novel antigen on the CD4+ lymphocytes by means of which it can bind CD4+ cells which express the antigen on the surface of CD4+ cells. The CD4+ subset cell population to which this antibody preferentially binds is the CD4+ helper-inducer population. This selectivity of the monoclonal antibody enables cell sorting, diagnostic and possible therapeutic applications thereof to be realized. The monoclonal antibody also reacts with CD8 cells, B cells and macrophages.
(FR) Anticorps monoclonal qui se lie préférentiellement à un sous-ensemble de la population des lymphocytes CD4 humains permettant de différencier de manière positive et précise entre les cellules inductrices d'assistants et inductrices de suppresseurs dans la population des cellules CD4+. L'anticorps monoclonal reconnaît un nouvel antigène sur les lymphocytes CD4+ qui expriment l'antigène sur la surface des cellules CD4+. La population cellulaire du sous-ensemble CD4+ à laquelle ledit anticorps se lie de manière préférentiellement est la population d'inducteurs d'assistants CD4+. Cette sélectivité de l'anticorps monoclonal permet de trier les cellules, et de réaliser des diagnostics et des applications thérapeutiques. L'anticorps monoclonal réagit également avec les cellules CD8, les cellules B et les macrophages.
Designated States: AU, CA, JP
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0593446CA2069501AU1991068994