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1. (WO1991007982) TREATMENT OF HSV
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/007982 International Application No.: PCT/US1990/006962
Publication Date: 13.06.1991 International Filing Date: 29.11.1990
Chapter 2 Demand Filed: 27.06.1991
IPC:
A61K 31/185 (2006.01) ,A61K 38/00 (2006.01) ,A61K 38/16 (2006.01) ,C07K 14/50 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
475
Growth factors; Growth regulators
50
Fibroblast growth factor (FGF)
Applicants:
THE SALK INSTITUTE FOR BIOLOGICAL STUDIES [US/US]; 10010 North Torrey Pines Road La Jolla, CA 92037, US (AllExceptUS)
CORNELL RESEARCH FOUNDATION, INC. [US/US]; 20 Fornwood Drive Suite 105 Ithaca, NY 14850, US (AllExceptUS)
BAIRD, Jacques, Andrew, Cloutier [CA/US]; US (UsOnly)
HAJJAR, David, Phillip [US/US]; US (UsOnly)
Inventors:
BAIRD, Jacques, Andrew, Cloutier; US
HAJJAR, David, Phillip; US
Agent:
WATT, Phillip, H. ; Fitch, Even, Tabin & Flannery Room 900 135 South LaSalle Street Chicago, IL 60603, US
Priority Data:
443,93930.11.1989US
Title (EN) TREATMENT OF HSV
(FR) TRAITEMENT DU HSV
Abstract:
(EN) Basic fibroblast growth factor, a 146 amino acid residue polypeptide, analogs thereof, a lectin, suramin, protamine and/or a shortened fragment of either bFGF or of an analog thereof is used to prevent the spread of HSV-1. It has been found that topical application of an effective amount of such an agent prevents HSV uptake and/or infection in cells that are otherwise targets for such virus. One group of preferred agents are peptides which include the decapeptide sequence of a mammalian bFGF(106-115), e.g., bovine bFGF(106-115), examples of such preferred peptides include bovine bFGF(103-120)-NH2 and human bFGF(103-120)-NH2.
(FR) Un facteur de croissance de base de fibroblaste, un polypeptide de 146 restes d'acides aminés, des analogues de ce dernier, une lectine, une suramine, une protamine et/ou un fragment raccourci de bFGF ou d'un de ses analogues est utilisé pour empêcher la propagation du HSV-1. On a trouvé que l'application topique d'une dose efficace d'un tel agent empêche la contamination et/ou l'infection par le HSV de cellules qui seraient sinon des cibles pour ce virus. Un groupe d'agents à employer de préférence sont les peptides qui comportent la séquence décapeptide d'un bFGF (106-115), par exemple le bFGF(106-115) bovin. Des exemples de ces peptides à utiliser de préférence comportent le bFGF(103-120)-NH2 bovin et le bFGF(103-120)-NH2 humain.
Designated States: AU, CA, JP, KR, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1991071675