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1. (WO1991007977) PEPTIDES AND ANTIBODIES THAT INHIBIT INTEGRIN-LIGAND BINDING
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/007977 International Application No.: PCT/US1990/006954
Publication Date: 13.06.1991 International Filing Date: 29.11.1990
Chapter 2 Demand Filed: 28.06.1991
IPC:
A61K 38/00 (2006.01) ,C07K 14/705 (2006.01) ,C07K 16/28 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
Applicants:
SCRIPPS CLINIC AND RESEARCH FOUNDATION [US/US]; 10666 North Torrey Pines Road La Jolla, CA 92037, US
Inventors:
PLOW, Edward, F.; US
D'SOUZA, Stanley, E.; US
GINSBERG, Mark, H.; US
Agent:
BINGHAM, Douglas, A.; Dressler, Goldsmith, Shore, Sutker & Milnamow, Ltd. 11300 Sorrento Valley Road Suite 200 San Diego, CA 92121 , US
FITTING, Thomas; Dressler, Goldsmith, Shore, Sutker & Milnamow, Ltd. 11300 Sorrento Valley Road Suite 200 San Diego, CA 92121, US
Priority Data:
444,77701.12.1989US
Title (EN) PEPTIDES AND ANTIBODIES THAT INHIBIT INTEGRIN-LIGAND BINDING
(FR) PEPTIDES ET ANTICORPS INHIBANT LA LIAISON INTEGRINE-LIGAND
Abstract:
(EN) Polypeptides derived from the ligand-binding portion af an Integrin alpha subunit are disclosed as are their use for modulation of Integrin ligand binding. Anti-peptide antibodies, hybridomas secreting the antibodies, as well as methods of making and using such antibodies and recombinant DNA molecules coding for the polypeptides are also described. The polypeptides and antibodies to the polypeptides are effective inhibitors of fibrinogen binding to platelets.
(FR) Polypeptides dérivés de la partie de liaison de ligands de la sous-unité alpha de l'intégrine, ainsi que leur emploi dans la modulation de la liaison de ligands de l'intégrine. Sont également décrits des anticorps antipeptidiques, d'hybridomes sécrétant les anticorps, ainsi que des procédés de fabrication et d'utilisation desdits anticorps et des molécules d'ADN de recombinaison codant pour les polypeptides. Les polypeptides et les anticorps contre les polypeptides sont des inhibiteurs efficaces de la liaison de fibrinogène aux plaquettes.
Designated States: AU, CA, DK, ES, FI, JP, NO
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
FI922454NO19922155EP0502124JP3315403JPH05502228CA2069902
AU1991069113