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1. (WO1991007976) ANTI-THROMBOTIC PEPTIDES AND PSEUDOPEPTIDES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/007976 International Application No.: PCT/US1990/006935
Publication Date: 13.06.1991 International Filing Date: 28.11.1990
Chapter 2 Demand Filed: 26.06.1991
IPC:
A61K 38/00 (2006.01) ,C07K 5/02 (2006.01) ,C07K 5/11 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
5
Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
02
containing at least one abnormal peptide link
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
5
Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04
containing only normal peptide links
10
Tetrapeptides
11
the side chain of the first amino acid containing more amino groups than carboxyl groups, or derivatives thereof, e.g. Lys, Arg
Applicants:
RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. [US/US]; 40 Cape Henlopen Drive Lewes, DE 19958, US (AllExceptUS)
KLEIN, Scott, I. [US/US]; US (UsOnly)
MOLINO, Bruce, F. [US/US]; US (UsOnly)
Inventors:
KLEIN, Scott, I.; US
MOLINO, Bruce, F.; US
Agent:
SAVITZKY, Martin, F. ; Rhône-Poulenc Rorer Inc. 500 Arcola Road P.O. Box 1200 Collegeville, PA 19426 , US
Priority Data:
444,48401.12.1989US
Title (EN) ANTI-THROMBOTIC PEPTIDES AND PSEUDOPEPTIDES
(FR) PEPTIDES ANTI-THROMBOSE ET PSEUDOPEPTIDES
Abstract:
(EN) Disclosed are novel peptides and pseudopeptides and pharmaceutical compositions thereof that inhibit platelet aggregation and thrombus formation in mammalian blood of structure (I), wherein: X is H, amidino or (a); Y is H, amino or (b); Z is (c), OR1 or a naturally occuring L-amino acid, bounded to the carbon atom at the $g(a)-amino position; R is alkyl, aryl or aralkyl; R1 and R2 are independently H, alkyl, aryl, aralkyl or allyl; m is 1 through 5; n is 0 through 4; and pharmaceutically acceptable salts thereof.
(FR) On décrit des peptides et des pseudopeptides nouveaux ainsi que des compositions pharmaceutiques de ceux-ci inhibant l'accumulation de plaquettes et la formation d'un thrombus dans le sang mammifère de structure: (I) dans laquelle: X est H, amidino ou (a); Y est H, amino ou (b); Z est (c), OR1 ou un acide-aminé-L se produisant naturellement, lié à l'atome de carbone à la position amino-$g(a); R est un alcoyle, un aryle ou aralcoyle; R1 et R2 sont indépendamment H, un alcoyle, un aryle, un aralcoyle ou un allyle; m va de 1 à 5; n va de 0 à 4 et des sels pharmaceutiquement acceptables de ceux-ci.
Designated States: AU, CA, JP, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0502926CA2069754AU1991068900