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1. (WO1991007967) METHOD OF PREVENTING OR LIMITING REPERFUSION DAMAGE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/007967 International Application No.: PCT/EP1990/001985
Publication Date: 13.06.1991 International Filing Date: 19.11.1990
IPC:
A61K 31/495 (2006.01) ,C07D 241/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
241
Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
02
not condensed with other rings
04
having no double bonds between ring members or between ring members and non-ring members
Applicants:
JANSSEN PHARMACEUTICA N.V. [BE/BE]; Turnhoutseweg 30 B-2340 Beerse, BE (AllExceptUS)
VAN BELLE, Herman [BE/BE]; BE (UsOnly)
VAN LAERHOVEN, Willy, J., C. [BE/BE]; BE (UsOnly)
Inventors:
VAN BELLE, Herman; BE
VAN LAERHOVEN, Willy, J., C.; BE
Priority Data:
440,14222.11.1989US
Title (EN) METHOD OF PREVENTING OR LIMITING REPERFUSION DAMAGE
(FR) PROCEDE POUR EMPECHER OU LIMITER LES LESIONS LIEES A LA REPERFUSION
Abstract:
(EN) The use of an N-alkylpiperazinealkanamide for preventing and/or limiting reperfusion damage upon reperfusion of an organ or muscular tissue, particularly in a patient undergoing thrombolysis or reperfusion of the heart after open heart surgery or after receiving a donor heart. The use of an N-alkylpiperazinealkanamide for preventing and/or limiting reperfusion damage upon reperfusion of a transplanted heart. The use of an N-alkylpiperazinealkanamide for storing a heart for transplantation for at least 24 hours in a cold cardioplegic solution. Compositions comprising an effective reperfusion damage preventing and/or limiting amount of an N-aryl-piperazinealkanamide derivative and optionally further comprising a thrombolytic agent and/or cyclodextrin or an ether derivative thereof. Processes for preparing such compositions. Novel N-alkylpiperazinealkanamide compounds and a process for preparing said compounds.
(FR) Emploi d'un N-alkylpipérazinealkanamide pour empêcher et/ou limiter les lésions lors de la reperfusion d'un organe ou d'un tissu musculaire, notamment chez un patient subissant une thrombolyse ou la reperfusion du c÷ur après une opération à c÷ur ouvert ou après avoir reçu un c÷ur de donneur. Emploi d'un N-alkylpipérazinealkanamide pour empêcher et/ou limiter les lésions lors de la reperfusion d'un c÷ur transplanté. Emploi d'un N-alkylpipérazinealkanamide pour stocker un c÷ur destiné à la transplantation pendant au moins 24 heures dans une solution cardioplégique froide. Compositions comprenant une dose efficace, empêchant et/ou limitant les lésions liés à la reperfusion, d'un dérivé de N-aryle-pipérazinealkanamide et comprenant en outre éventuellement un agent thrombolytique et/ou une cyclodextrine ou son dérivé d'éther. Procédés pour préparer de telles compositions. Nouveaux composés de N-alkylpipérazinealkanamide et procédé pour préparer lesdits composés.
Designated States: AU, BB, BG, BR, CA, FI, HU, JP, KP, KR, LK, MC, MG, MW, NO, RO, SD, SU, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CM, GA, ML, MR, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
FI913433NO19912511NO19982078IL96390ZA1990/09345EP0455789
RU02093156CA2044143KR1019920700644AU1991068763DK0577171