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1. (WO1991007951) HOMOLOGOUS GULURONIC ACID ALGINATE COATING COMPOSITION FOR IN-VIVO APPLICATION AND IMPLANTATION AND METHOD OF USING SAME
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/007951 International Application No.: PCT/US1990/007108
Publication Date: 13.06.1991 International Filing Date: 04.12.1990
Chapter 2 Demand Filed: 25.04.1991
IPC:
A61K 9/16 (2006.01) ,A61K 9/50 (2006.01) ,A61L 27/20 (2006.01) ,C08L 5/04 (2006.01) ,C12N 11/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
14
Particulate form, e.g. powders
16
Agglomerates; Granulates; Microbeadlets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
50
Microcapsules
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
14
Macromolecular materials
20
Polysaccharides
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
L
COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
5
Compositions of polysaccharides or of their derivatives not provided for in group C08L1/ or C08L3/142
04
Alginic acid; Derivatives thereof
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
11
Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
02
Enzymes or microbial cells being immobilised on or in an organic carrier
04
entrapped within the carrier, e.g. gel, hollow fibre
Applicants:
TRANCEL CORPORATION [US/US]; 1202 E. Wakeham Avenue Santa Ana, CA 92705, US
SKJAK-BRAEK, Gudmund [NO/NO]; NO
SMIDSROD, Olav [NO/NO]; NO
ESPEVIK, Terje [NO/NO]; NO
OTTERLEI, Marit [NO/NO]; NO
Inventors:
SKJAK-BRAEK, Gudmund; NO
SMIDSROD, Olav; NO
ESPEVIK, Terje; NO
OTTERLEI, Marit; NO
SOON-SHIONG, Patrick; US
Agent:
GERIAK, James, W. ; 611 West Sixth Street 34th Floor Los Angeles, CA 90017, US
Priority Data:
446,46205.12.1989US
Title (EN) HOMOLOGOUS GULURONIC ACID ALGINATE COATING COMPOSITION FOR IN-VIVO APPLICATION AND IMPLANTATION AND METHOD OF USING SAME
(FR) COMPOSITION DE REVÊTEMENT A BASE D'ALGINATE COMPRENANT DE L'ACIDE GULURONIQUE HOMOLOGUE DESTINEE A ETRE APPLIQUEE ET IMPLANTEE IN VIVO ET PROCEDE D'UTILISATION
Abstract:
(EN) Disclosed is a transplantation or implantation composition which provokes a reduced immune response comprising materiel encapsulated within a physical semi-permeable barrier. At least the outermost layer of the barrier contains alginate comprised substantially of $g(a)-1-guluronic acid with minor amounts $g(b)-D-mannuronic acid. The methods of making such a composition and use of the same are also disclosed.
(FR) On décrit une composition de greffe ou d'implantation qui entraîne une réponse immunitaire réduite comprenant du matériau ancapsulé à l'intérieur d'une barrière semi-perméable. Au moins la couche la plus externe de la barrière contient de l'alginate comprenant essentiellement de l'acide guluronique $g(a)-1 avec des quantités minimes d'acide mannuronique $g(b)-D. On décrit également les procédés permettant de fabriquer une telle composition et l'utilisation de celle-ci.
Designated States: AT, FI, JP, KR, NO
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0502949JPH05502863