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1. (WO1991007664) DIAGNOSTIC PROTEINS TO TEST FOR MORE THAN ONE ANTIBODY
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/007664 International Application No.: PCT/US1990/006621
Publication Date: 30.05.1991 International Filing Date: 13.11.1990
IPC:
C07K 14/15 (2006.01) ,C07K 14/16 (2006.01) ,G01N 33/569 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
08
RNA viruses
15
Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
08
RNA viruses
15
Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
155
Lentiviridae, e.g. human immunodeficiency virus (HIV), visna-maedi virus, equine infectious anaemia virus
16
HIV-1
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
569
for micro-organisms, e.g. protozoa, bacteria, viruses
Applicants:
CAMBRIDGE BIOTECH CORPORATION [US/US]; 365 Plantation Street Biotechnology Research Park Worcester, MA 01605, US
Inventors:
YOUNG, Elihu, M.; US
STOREY, James, R.; US
BELTZ, Gerald, A.; US
Agent:
GOLDSTEIN, Jorge, A. ; Sterne, Kessler, Goldstein & Fox 1225 Connecticut Avenue, N.W. Suite 300 Washington, DC 20036, US
Priority Data:
433,70913.11.1989US
Title (EN) DIAGNOSTIC PROTEINS TO TEST FOR MORE THAN ONE ANTIBODY
(FR) PROTEINES DE DIAGNOSTIC UTILISEES POUR TESTER PLUS D'UN ANTICORPS
Abstract:
(EN) This invention is directed to the discovery that certain envelope peptide fragments of the Human Immunodeficiency Virus 2 (HIV-2) are particularly immunoreactive against HIV-2 antibodies. These fragments can therefore be applied to immunodiagnostic tests for the detection of antibodies to HIV-2. This invention is also directed to certain chimeric proteins that are made from immunogenic portions of the envelope gene of HIV-2, HIV-1, or HTLV-I that can be used to test for antibodies to HIV-2, HIV-1, and HTLV-I and HTLV-II.
(FR) L'invention a trait à la découverte que certains fragments peptidiques d'enveloppe du virus-2 d'immunodéficience humaine (VIH-2) sont particulièrement immunoréactifs contre des anticorps du VIH-2. Par conséquent, on peut appliquer ces fragments à des tests d'immunodiagnostic permettant la détection d'anticorps contre le VIH-2. L'invention a également trait à certaines protéines chimériques obtenues à partir de parties immunogènes du gène d'enveloppe du VIH-2, VIH-1, ou le HTLV-I, que l'on peut utiliser dans des tests visant à déterminer la présence d'anticorps contre le VIH-2, le VIH-1, le HTLV-I et le HTLV-II.
Designated States: CA, JP
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0453563JPH04502773CA2045524