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1. (WO1991007504) IMPROVED DNA POLYMERISATION DEVICE
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CLAIMS: - 1. A device for use in DNA polymerisation, the device comprising an element adapted to receive tubes in which the DNA polymerisation reaction is to take place and being provided with heating means adapted to heat the element, a heat sink adapted to remove heat from the element and movement means enabling the movement of the element and the heat sink into and out of contact with each other.

2. A device as claimed in claim 1, in which the element remains stationary and the heat sink is moved into and out of contact with the element.
3. A device as claimed in claim 1 or 2 , in which the mass of the heat sink is substantially greater than the mass of the element.
4. A device as claimed in claim 3, in which the mass of the heat sink is two to three times the mass of the element.
5. A device as claimed in any one of claims 1 to , in which the heat sink is provided with cooling means
selected from the group consisting of a fan directed on the heat sink, Peltier effect coolers provided within the heat sink or a combination thereof.
6. A method of DNA amplification using polymerase chain reaction, the method being characterized in that a
reaction mixture comprising DNA, suitable thermostable DNA polymeraseε and oligo nucleotide primers in a vessel is placed in an element adapted to receive the vessel, the element being provided with heating means, heating the reaction mixture by actuation of the heating means, stopping the heating means, cooling the reaction mixture by bringing a heat sink into contact with the element, moving the heat sink away from the element and cyclically repeating the heating and cooling steps.
7. A method as claimed in claim 6, in which the element remains stationary and the heating sink is moved into and out of contact with the element.
8. A method as claimed in claim 6 or claim 7, in which the mass of the heat sink is substantially greater than the mass of the element.
9. A method as claimed in claim 8, in which the mass of the heat sink is two to three times the mass of the element.
10. A method as claimed in any one of claims 6 to 9, in which the heat sink is provided with cooling means selected from the group consisting of a fan directed on the heat sink, Peltier effect coolers provided within the heat sink and combinations thereof.