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1. (WO1991007501) ENZYMATIC RESOLUTION OF ENDO-BICYCLO[2.2.1]HEPTAN-2-OL AND DERIVED PHARMACEUTICAL AGENTS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/007501 International Application No.: PCT/US1989/005228
Publication Date: 30.05.1991 International Filing Date: 13.11.1989
Chapter 2 Demand Filed: 20.02.1991
IPC:
C07C 45/71 (2006.01) ,C07C 47/575 (2006.01) ,C07C 235/34 (2006.01) ,C07C 255/37 (2006.01) ,C07D 239/10 (2006.01) ,C12P 7/02 (2006.01) ,C12P 41/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
45
Preparation of compounds having CO groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
61
by reactions not involving the formation of CO groups
67
by isomerisation; by change of size of the carbon skeleton
68
by increase in the number of carbon atoms
70
by reaction with functional groups containing oxygen only in singly bound form
71
being hydroxy groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
47
Compounds having -CHO groups
52
Compounds having -CHO groups bound to carbon atoms of six-membered aromatic rings
575
containing ether groups, groups, groups, or groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
235
Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
02
having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
32
the carbon skeleton containing six-membered aromatic rings
34
having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
255
Carboxylic acid nitriles
01
having cyano groups bound to acyclic carbon atoms
32
having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
37
the carbon skeleton being further substituted by etherified hydroxy groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
239
Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02
not condensed with other rings
06
having one double bond between ring members or between a ring member and a non-ring member
08
with hetero atoms directly attached in position 2
10
Oxygen or sulfur atoms
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7
Preparation of oxygen-containing organic compounds
02
containing a hydroxy group
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
41
Processes using enzymes or micro-organisms to separate optical isomers from a racemic mixture
Applicants:
PFIZER INC. [US/US]; 235 East 42nd Street New York, NY 10017, US (AllExceptUS)
SACCOMANO, Nicholas, A. [US/US]; US (UsOnly)
Inventors:
SACCOMANO, Nicholas, A.; US
Agent:
RICHARDSON, Peter, C. ; Pfizer Inc. 235 East 42nd Street New York, NY 10017, US
Priority Data:
Title (EN) ENZYMATIC RESOLUTION OF ENDO-BICYCLO[2.2.1]HEPTAN-2-OL AND DERIVED PHARMACEUTICAL AGENTS
(FR) RESOLUTION ENZYMATIQUE DE ENDO-BICYCLO[2.2.1]HEPTANE-2-OL ET AGENTS PHARMACEUTIQUES DERIVES
Abstract:
(EN) Process for the pancreatic lipase mediated transesterification method for the optical resolution of $i(endo)-norborneol; derived optically active 5-(3-(exo-bicyclo[2.2.1]hept-2-yloxy)-4-methoxyphenyl)-3,4,5,6-tetrahydropyrimidin-2(1H)-ones; and stepwise process and intermediates therefor.
(FR) Procédé pour la transestérification induite par lipase pancréatique pour la résolution optique de $i(endo)-norbornéol; 5-(3-(exo-bicyclo[2.2.1]hept-2-yloxy)-4-methoxyphényle)-3,4,5,6-tétrahydropyrimidine-2(1H)-ones dérivées optiquement actives; et procédé par étapes et intermédiaires utilisés.
Designated States: FI, HU, NO, RO, SU, US
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
FI922142NO19921876RU02104306US5270206JP3173871