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1. (WO1991007500) SPECIFIC BINDING AGENTS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/007500 International Application No.: PCT/GB1990/001755
Publication Date: 30.05.1991 International Filing Date: 14.11.1990
Chapter 2 Demand Filed: 07.05.1991
IPC:
A61K 38/00 (2006.01) ,A61K 39/395 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
Applicants:
UNILEVER PLC [GB/GB]; Unilever House Blackfriars London EC4P 4BQ, GB (AU, CA)
UNILEVER N.V. [NL/NL]; Burgemeester 's Jacobplein 1 P.O. Box 760 NL-3000 DK Rotterdam, NL (BG, FI, HU, JP, KR, NO, RO, SU)
VERHOEYEN, Martine, Elisa [BE/GB]; GB (UsOnly)
Inventors:
VERHOEYEN, Martine, Elisa; GB
Agent:
BUTLER, David, John; Patent Division Unilever plc Unilever House Blackfriars London EC4P 4BQ, GB
Priority Data:
8926045.917.11.1989GB
9019552.007.09.1990GB
Title (EN) SPECIFIC BINDING AGENTS
(FR) AGENTS DE LIAISON SPECIFIQUES
Abstract:
(EN) A reshaped human antibody or reshaped human antibody fragment having specificity for human placental alkaline phosphatase (PLAP) is produced by transferring the complementarity determining regions (CDRs) from a murine anti-PLAP hybridoma cell line H17E2 into a human antibody variable region framework. The reshaped molecule can be used in the treatment or diagnosis of cancer.
(FR) On produit un anticorps humain refaçonné ou un fragment d'anticorps humain refaçonné présentant une spécificité à l'égard de la phosphatase alcaline placentaire humaine (PAPH), par transfert des régions déterminantes complémentaires (RDC) d'une lignée cellulaire d'hybridomes H17E2 anti-PAPH murine, dans une structure de régions variables d'anticorps humains. On peut utiliser la molécule refaçonnée dans le traitement ou le diagnostic du cancer.
Designated States: AU, BG, CA, FI, HU, JP, KR, NO, RO, SU, US
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
FI922220NO19921941NO19980656RU02102479CA2066670KR1019970007783*
KR1019920703837AU1990067369