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1. (WO1991007499) THE SCL GENE, AND THE ENCODED HEMATOPOIETIC FACTOR
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/007499 International Application No.: PCT/US1990/006544
Publication Date: 30.05.1991 International Filing Date: 16.11.1990
Chapter 2 Demand Filed: 16.11.1990
IPC:
A61K 38/00 (2006.01) ,C07K 14/47 (2006.01) ,C07K 14/475 (2006.01) ,C07K 14/52 (2006.01) ,C07K 14/82 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
47
from mammals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
475
Growth factors; Growth regulators
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
52
Cytokines; Lymphokines; Interferons
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
82
Translation products from oncogenes
Applicants:
THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, U.S. DEPARTMENT OF COMMERCE [US/US]; 5285 Port Royal Road Springfield, VA 22161, US
Inventors:
KIRSCH, Ilan, R.; US
BEGLEY, C., Glenn; AU
Agent:
HOLMAN, John, Clarke ; Fleit, Jacobson, Cohn, Price, Holman & Stern The Jenifer Building 400 Seventh Street, N.W. Washington, DC 20004, US
Priority Data:
437,81917.11.1989US
Title (EN) THE SCL GENE, AND THE ENCODED HEMATOPOIETIC FACTOR
(FR) GENE SCL ET FACTEUR HEMATOPOIETIQUE CODE
Abstract:
(EN) We have identified a new human gene, SCL. We discovered this gene because of its involvement in a chromosomal translocation associated with the occurrence of a stem cell leukemia manifesting myeloid and lymphoid differentiation capabilities. Here we report the sequence of a cDNA for the normal SCL transcript, as well as for an aberrant fusion transcript produced in the leukemia cells. Although different at their 3' untranslated regions, both cDNAs predict a protein with primary amino acid sequence homology to the previously described amphipathic helix-loop-helix DNA binding and dimerization motif of the Lyl-1, myc, MyoD, Ig enhancer binding, daughterless, and achaete-scute families of genes. For these cDNAs, two forms of the SCL protein (greater than 20 and 30 kD) are predicted, both of which retain this putative DNA binding domain. The pattern of expression of SCL mRNA is primarily predominant in early hematopoietic tissues. Taken together, these studies lead to the speculation that SCL plays a role in differentiation and/or commitment events during hematopoiesis.
(FR) On a identifié un nouveau gène humain SCL. On a découvert ce gène à cause de son implication dans la translocation chromosomique associée à l'apparition d'une leucémie à cellules souches manifestant des capacités de différentiation myéloïde et lymphoïde. On rapporte ici la séquence d'un ADN complémentaire au transcript du SCL normal, et à un transcript de fusion aberrant produit dans les cellules leucémiques. Bien qu'il soient différents au niveau de leurs régions non traduites 3', les deux ADN complémentaires prédisent une protéine présentant une homologie avec la liaison d'ADN en hélice-boucle-hélice amphipathique préalablement décrite, et le motif de dimérisation des familles de gènes à liaison par exaltateur de Lyl-1, myc, MyoD, Ig, sans fille, et achaete-scute. Pour ces ADN complémentaires, deux formes de la protéine du SCL (supérieure à 20 et 30 kD) sont prédites, retenant l'une et l'autre ce domaine de liaison d'ADN putatif. La configuration d'expression d'ARN messager du SCL est à l'origine prédominante dans les tissus hématopoïétiques précoces. Ces études regroupées conduisent à la spéculation que le SCL joue un rôle dans les évènements de différentiation et/ou de placement pendant l'hématopoïèse.
Designated States: AU, CA, JP
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1991069109