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1. (WO1991007488) BETA RETINOIC ACID RESPONSE ELEMENTS COMPOSITIONS AND ASSAYS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/007488 International Application No.: PCT/US1990/006626
Publication Date: 30.05.1991 International Filing Date: 13.11.1990
Chapter 2 Demand Filed: 04.06.1991
IPC:
C07K 14/705 (2006.01) ,C12N 15/85 (2006.01) ,G01N 33/50 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
Applicants:
THE SALK INSTITUTE FOR BIOLOGICAL STUDIES [US/US]; 10010 North Torrey Pines Road La Jolla, CA 92037, US
Inventors:
SUCOV, Henry, Michael; US
EVANS, Ronald, Mark; US
Agent:
CAMPBELL, Cathryn ; Pretty, Schroeder, Brueggemann & Clark 444 South Flower Street Suite 2000 Los Angeles, CA 90071, US
Priority Data:
438,75716.11.1989US
Title (EN) BETA RETINOIC ACID RESPONSE ELEMENTS COMPOSITIONS AND ASSAYS
(FR) ELEMENTS DE REPONSE DE L'ACIDE RETINOIQUE BETA; COMPOSITIONS ET ANALYSES
Abstract:
(EN) The present invention provides transcriptional control regions, expression vectors comprising said regions, mammalian cells transformed to transcribe and express genes from said vectors, and various methods of assaying compounds for hormone agonist or antagonist activity, all based on discovery of response elements of the $g(b)-retinoic acid receptor and of the activation of said response elements in all mammalian cells without need to transform the cells to express the receptor independently of endogenous expression thereof.
(FR) On décrit des régions de commande de transcription, des vecteurs d'expression comprenant lesdites régions, des cellules de mammifère transformées de façon à transcrire et exprimer les gènes desdits vecteurs, et diverses méthodes permettant d'analyser des composés au niveau de l'activité agoniste ou antagoniste d'hormones, toutes basées sur la découverte d'éléments de réponse du récepteur d'acide rétinoïque $g(b) et de l'activation desdits éléments de réponse dans toutes les cellules de mammifère sans faire appel à une transformation des cellules de manière à exprimer le récepteur indépendamment de l'expression endogène de celui-ci.
Designated States: AU, CA, JP
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0502979CA2072644AU1991069568