Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO1991007432) ANTIHEMOSTATIC FACTOR VII PEPTIDES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/007432 International Application No.: PCT/US1990/006617
Publication Date: 30.05.1991 International Filing Date: 13.11.1990
Chapter 2 Demand Filed: 13.06.1991
IPC:
A61K 38/00 (2006.01) ,C07K 16/40 (2006.01) ,C12N 9/64 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
40
against enzymes
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
48
acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
50
Proteinases
64
derived from animal tissue, e.g. rennin
Applicants:
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM [US/US]; 201 West 7th Street Austin, TX 78701, US
Inventors:
FAIR, Daryl, S.; US
KUMAR, Anuradha; US
Agent:
PATTERSON, Melinda, L.; Arnold, White & Durkee P.O. Box 4433 Houston, TX 77210, US
DOST, Wolfgang; Galileiplatz 1 81679 München, DE
Priority Data:
435,65713.11.1989US
Title (EN) ANTIHEMOSTATIC FACTOR VII PEPTIDES
(FR) PEPTIDES ANTIHEMOSTATIQUES DU FACTEUR VII
Abstract:
(EN) A number of novel antihemostatic peptides are claimed. Included among the antihemostatic peptides claimed are: R-T-K-L-F-W-I-S-Y-SD-G-D-Q, Y-S-D-G-D-Q-C, L-L-V-N-G-A-Q-L-C, C-F-D-K-I-K-N-W-R-N-L-I-A-V-L-G-E-H-D-L-S, F-D-K-I-K-N-W-R-N-L-I-A-V-L-G-E-H-D-L-S-E-H-D-G-D-E-Q-S-R-R-V-A-Q-V-I, L-G-E-H-D-L-S-E-H-D-G-D-E-Q-S-R-R-V-A-Q-V-I, A-V-L-G-E-H-D-L-S-E-H-D-G, V-R-F-S-L-V-S-G-W-G-Q, G-Q-L-L-D-R-G-A-T-A-L-E-L-M-V-L-N-V-P-R-L, A-G-Y-S-D-G-S-K-D-S-C, P-H-A-T-H-Y-R-G-T-W-Y-L-T-G-I and V-Y-T-R-V-S-Q-Y-I-E-W-L-Q-K-L and their analogues. The peptides are useful for inhibiting the formation of the Factor VII-tissue factor macromolecular complex or for inhibiting the activation of Factor X by Factor VII.
(FR) Un certain nombre de nouveaux peptides antihémostatiques est décrit. Sont décrits et compris parmi les peptides antihémostatiques les séquences R-T-K-L-F-W-I-S-Y-S-D-G-D-Q, Y-S-D-G-D-Q-C, L-L-V-N-G-A-Q-L-C, C-F-D-K-I-K-N-W-R-N-L-I-A-V-L-G-E-H-D-L-S, F-D-K-I-K-N-W-R-N-L-I-A-V-L-G-E-H-D-L-S-E-H-D-G-D-E-Q-S-R-R-V-A-Q-V-I, L-G-E-H-D-L-S-E-H-D-G-D-E-Q-S-R-R-V-A-Q-V-I, A-V-L-G-E-H-D-L-S-E-H-D-G, V-R-F-S-L-V-S-G-W-G-Q, G-Q-L-L-D-R-G-A-T-A-L-E-L-M-V-L-N-V-P-R-L, A-G-Y-S-D-G-S-K-D-S-C, P-H-A-T-H-Y-R-G-T-W-Y-L-T-G-I et V-Y-T-R-V-S-Q-Y-I-E-W-L-Q-K-L ainsi que leurs analogues. Les peptides sont utiles pour inhiber la formation du complexe macromoléculaire facteur VII-facteur tissulaire, ou pour inhiber l'activation du facteur X par le facteur VII.
Designated States: AT, AU, BB, BG, BR, CA, CH, DE, DK, ES, FI, GB, HU, JP, KP, KR, LK, LU, MC, MG, MW, NL, NO, RO, SD, SE, SU
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CM, GA, ML, MR, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0500800AU1991069634