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1. (WO1991007404) DIAZINE DERIVATIVES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/007404 International Application No.: PCT/GB1990/001776
Publication Date: 30.05.1991 International Filing Date: 19.11.1990
IPC:
C07D 471/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants:
IMPERIAL CHEMICAL INDUSTRIES PLC [GB/GB]; Imperial Chemical House Millbank London SW1P 3JF, GB
Inventors:
ROBERTS, David, Anthony; GB
PEARCE, Robert, James; GB
BRADBURY, Robert, Hugh; GB
LUKE, Richard, William, Arthur; GB
Agent:
SMITH, Stephen, Collyer; ICI Group Patent Services Department P.O. Box 6, Bessemer Road Welwyn Garden City Hertfordshire AL7 1HD, GB
Priority Data:
8926211.720.11.1989GB
9011348.121.05.1990GB
Title (EN) DIAZINE DERIVATIVES
(FR) DERIVES DE DIAZINE
Abstract:
(EN) Compounds of formula (I) where ring B is a pyridine, pyridazine, pyrimidine or pyrazine moiety; X is phenylene optionally bearing a substituent selected from (1-4C)alkyl, (1-4C)alkoxy, halogeno, trifluoromethyl, cyano and nitro, or X is a direct bond between the adjacent phenyl and methylene groups; Z is 1 $i(H)-tetrazol-5-yl, -CO.NH.(1 $i(H)-tetrazol-5-yl) or a group of the formula -CO.OR6 or -CO.NH.SO2.R7. The compounds are of value in treating conditions such as hypertentions and congestive heart failure. The inventio further concerns processes for the manufacture of the novel compounds and the use of the compounds in medical treatment.
(FR) Composés de la formule (I), dans laquelle l'anneau B représente une fraction pyridine, pyridazine, pyrimidine ou pyrazine; X représente phénylène supportant facultativement un substituant choisi entre alkyle contenant 1 à 4 atomes de carbone, alcoxy contenant 1 à 4 atomes de carbone, alcoxy contenant 1 à 4 atomes de carbone, halogéno, trifluorométhyle, cyano et nitro, ou X représente une liaison directe entre les groupes phényle et méthylène adjacents; Z représente 1 $i(H)-tétrazol-5-yle, -CO.NH.(1 $i(H)-tétrazol-5-yle) ou un groupe de la formule -CO.OR6 ou -CO.NH.SO2R7. Les composés sont efficaces dans le traitement d'états tels que l'hypertension et l'insuffisance cardiaque. L'invention concerne également des procédés de fabrication des nouveaux composés, ainsi que l'emploi de ceux-ci en traitement médical.
Designated States: AU, BG, FI, HU, JP, KR, NO, RO, SU
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
FI913478NO19912843EP0454831KR1019920701206AU1990067336