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1. (WO1991007368) PREPARATION METHOD FOR $g(a),$g(b)-UNSATURATED KETONES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/007368 International Application No.: PCT/JP1990/001489
Publication Date: 30.05.1991 International Filing Date: 15.11.1990
IPC:
C07C 45/66 (2006.01) ,C07C 45/72 (2006.01) ,C07C 45/74 (2006.01) ,C07C 205/45 (2006.01) ,C07C 319/20 (2006.01) ,C07C 323/22 (2006.01) ,C07D 307/12 (2006.01) ,C07D 309/06 (2006.01) ,C07D 335/02 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
45
Preparation of compounds having CO groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
61
by reactions not involving the formation of CO groups
65
by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
66
by dehydration
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
45
Preparation of compounds having CO groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
61
by reactions not involving the formation of CO groups
67
by isomerisation; by change of size of the carbon skeleton
68
by increase in the number of carbon atoms
72
by reaction of compounds containing CO groups with the same or other compounds containing CO groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
45
Preparation of compounds having CO groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
61
by reactions not involving the formation of CO groups
67
by isomerisation; by change of size of the carbon skeleton
68
by increase in the number of carbon atoms
72
by reaction of compounds containing CO groups with the same or other compounds containing CO groups
74
combined with dehydration
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
205
Compounds containing nitro groups bound to a carbon skeleton
45
the carbon skeleton being further substituted by at least one doubly-bound oxygen atom, not being part of a -CHO group
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
319
Preparation of thiols, sulfides, hydropolysulfides or polysulfides
14
of sulfides
20
by reactions not involving the formation of sulfide groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
323
Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
22
containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
307
Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
02
not condensed with other rings
04
having no double bonds between ring members or between ring members and non-ring members
10
with substituted hydrocarbon radicals attached to ring carbon atoms
12
Radicals substituted by oxygen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
309
Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
02
having no double bonds between ring members or between ring members and non-ring members
04
with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
06
Radicals substituted by oxygen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
335
Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
02
not condensed with other rings
Applicants:
NIPPON SODA CO., LTD. [JP/JP]; 2-1, Ohtemachi 2-chome Chiyoda-ku Tokyo 100, JP (AllExceptUS)
NAKAJIMA, Masashi [JP/JP]; JP (UsOnly)
KYOTANI, Tadashi [JP/JP]; JP (UsOnly)
SAWAKI, Mikio [JP/JP]; JP (UsOnly)
TSUKASHIMA, Keiichi [JP/JP]; JP (UsOnly)
Inventors:
NAKAJIMA, Masashi; JP
KYOTANI, Tadashi; JP
SAWAKI, Mikio; JP
TSUKASHIMA, Keiichi; JP
Agent:
YOKOYAMA, Yoshimi ; Nippon Soda Co., Ltd. 2-1, Ohtemachi 2-chome Chiyoda-ku Tokyo 100, JP
Priority Data:
1/29738917.11.1989JP
Title (EN) PREPARATION METHOD FOR $g(a),$g(b)-UNSATURATED KETONES
(FR) PROCEDE DE PREPARATION DE CETONES $g(a),$g(b)-INSATUREES
Abstract:
(EN) The present invention relates to a method for the preparation of $g(a),$g(b)-unsaturated ketones represented by general formula (II) (where R is as defined above) which comprises that aldehydes represented by general formula (III): RCHO (where R is as defined above) and acetone are reacted in the presence of one or two or more compounds selected from the group consisting of perhydroisoindole and pyrrolidine which may have substituents as catalysts, in a water solvent, at -40 °C to 60 °C, then acetone is distilled to remove, and a water-insoluble organic solvent is added to the remaining reaction solution to react in the presence of acid catalyst. Compound (II) is extremely important as intermediates for pharmaceuticals and agricultural chemicals.
(FR) Procédé de préparation de cétones $g(a),$g(b)-insaturées représentées par la formule générale (II), consistant à faire réagir des aldéhydes représentées par la formule générale (III): RCHO avec de l'acétone, en présence, en tant que catalyseur, d'un ou de plusieurs composés sélectionnés dans le groupe constitué de perhydroisoindole et de pyrrolidine pouvant comporter des substituants, dans un solvant aqueux, à une température comprise entre -40 et 60 °C, à éliminer ensuite l'acétone par distillation, et à ajouter un solvant organique insoluble dans l'eau à la solution de réaction restante, afin de provoquer une réaction en présence d'un catalyseur acide. Le composé (II) est extrêmement important en tant que produit intermédiaire dans la synthèse de produits chimiques pour l'industrie pharmaceutique et agricole.
Designated States: AU, BR, CA, KR, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0457911US5300654CA2044619DE000069003093KR1019920701104AU1990066409