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1. (WO1991006863) PYRIMIDINE BIOSYNTHESIS INHIBITORS USEFUL AS IMMUNOSUPPRESSIVE AGENTS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/006863 International Application No.: PCT/US1990/005942
Publication Date: 16.05.1991 International Filing Date: 22.10.1990
Chapter 2 Demand Filed: 22.04.1991
IPC:
A61K 31/12 (2006.01) ,A61K 31/66 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
12
Ketones
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
66
Phosphorus compounds
Applicants:
E.I. DU PONT DE NEMOURS AND COMPANY [US/US]; 1007 Market Street Wilmington, DE 19898, US
Inventors:
ACKERMAN, Neil, Richard; US
JAFFEE, Bruce, Donald; US
Agent:
DENNINGER, Douglas, E. ; E.I. du Pont de Nemours and Company Legal Department 1007 Market Street Wilmington, DE 19898, US
FERGUSON, Blair, Q.; E.I. Du Pont de Nemours and Company Legal/Patent Records Center 1007 Market Street Wilmington, DE 19898, US
Priority Data:
430,89131.10.1989US
Title (EN) PYRIMIDINE BIOSYNTHESIS INHIBITORS USEFUL AS IMMUNOSUPPRESSIVE AGENTS
(FR) INHIBITEURS DE BIOSYNTHESE DE PYRIMIDINE UTILES EN TANT QU'AGENTS IMMUNOSUPPRESSEURS
Abstract:
(EN) The pyrimidine biosynthesis inhibitors dichloroallyl lawsone, N-(phosphonoacetyl)-L-aspartic acid (PALA), pyrazofurin, and derivatives thereof, are useful as immunomodulatory and anti-inflammatory agents. Pharmaceutical formulations containing these compounds are useful for the treatment of autoimmune diseases, chronic inflammatory diseases, and of organ transplantation rejections.
(FR) Le dichloroallyle lawson, l'acide L-(phosphonoacétyle)-L-(APAL) le pyrazofurin, ainsi que leurs dérivés, sont des inhibiteurs de la biosynthèse de pyrimidine, utiles en tant qu'agents immunomodulateurs et anti-inflammatoires. Les formulations pharmaceutiques contenant ces composés sont utiles dans le traitement de maladies auto-immunes, de maladies inflammatoires chroniques, et de rejets de transplantations d'organes.
Designated States: AU, CA, JP, KR
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0500586JPH05504550CA2069313AU1990066143