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1. (WO1991006664) METHOD FOR SYNTHESIZING ADENOSINE PHOSPHATE DERIVATIVES AND DERIVATIVES THEREBY OBTAINED
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/006664 International Application No.: PCT/FR1990/000793
Publication Date: 16.05.1991 International Filing Date: 31.10.1990
Chapter 2 Demand Filed: 31.05.1991
IPC:
A61K 39/00 (2006.01) ,C07K 16/40 (2006.01) ,C12N 9/12 (2006.01) ,C12N 9/88 (2006.01) ,C12P 19/32 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
40
against enzymes
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10
Transferases (2.)
12
transferring phosphorus containing groups, e.g. kinases (2.7)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
88
Lyases (4.)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19
Preparation of compounds containing saccharide radicals
26
Preparation of nitrogen-containing carbohydrates
28
N-glycosides
30
Nucleotides
32
having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same-ring, e.g. purine nucleotides, nicotineamide-adenine dinucleotide
Applicants:
INSTITUT PASTEUR [FR/FR]; 25-28, rue du Dr.-Roux F-75724 Paris Cédex 15, FR
Inventors:
LACOMBE, Marie-Lise; FR
VERON, Michel; FR
MOCK, Michèle; FR
BARZU, Octavian; FR
SARFATI, Robert; FR
Agent:
GUTMANN, Ernest ; Ernest Gutmann-Yves Plasseraud S.A. 67, bld. Haussmann F-75008 Paris, FR
Priority Data:
89/1432831.10.1989FR
Title (EN) METHOD FOR SYNTHESIZING ADENOSINE PHOSPHATE DERIVATIVES AND DERIVATIVES THEREBY OBTAINED
(FR) PROCEDE DE SYNTHESE DE DERIVES D'ADENOSINE PHOSPHATE ET DERIVES OBTENUS
Abstract:
(EN) The method for synthesizing substituted adenosine phosphate derivatives is characterized in that it is carried out using an enzymatic means and by subjecting substituted cAMP derivatives to the action of a protein having adenyl cyclase activity, then by subjecting the ATP derivatives thereby obtained to the action of a protein having NDP kinase activity and coupled with a phosphate group consuming system, and in that the ATP derivatives thereby formed are recovered. These derivatives can be used in particular as laboratory reagents.
(FR) Le procédé de synthèse de dérivés substitués d'adénosine phosphate est caractérisé en ce qu'il est réalisé par voie enzymatique en soumettant des dérivés de cAMP substitués à l'action d'une protéine à activité adényl cyclase, puis les dérivés d'ATP obtenus à l'action d'une protéine à activité NDP kinase, couplée à un système consommateur de groupes phosphate et qu'on récupère les dérivés d'ATP formés. Ces dérivés sont utilisables notamment comme réactifs de laboratoire.
Designated States: CA, JP
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: French (FR)
Filing Language: French (FR)
Also published as:
EP0498838