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1. (WO1991006658) INFECTIVE PROTEIN DELIVERY SYSTEM
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/006658 International Application No.: PCT/US1990/006141
Publication Date: 16.05.1991 International Filing Date: 23.10.1990
Chapter 2 Demand Filed: 02.04.1991
IPC:
A61K 9/50 (2006.01) ,C07K 14/525 (2006.01) ,C07K 14/57 (2006.01) ,C12N 15/867 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
50
Microcapsules
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
52
Cytokines; Lymphokines; Interferons
525
Tumour necrosis factor (TNF)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
52
Cytokines; Lymphokines; Interferons
555
Interferons (IFN)
57
IFN-gamma
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
86
Viral vectors
867
Retroviral vectors
Applicants:
CETUS CORPORATION [US/US]; 1400 Fifty-Third Street Emeryville, CA 94608, US
Inventors:
KRIEGLER, Michael; US
PEREZ, Carl, F.; US
Agent:
GIOTTA, Gregory, J.; Cetus Corporation 1400 Fifty-Third Street Emeryville, CA 94608, US
Priority Data:
426,98624.10.1989US
474,16902.02.1990US
488,70602.03.1990US
Title (EN) INFECTIVE PROTEIN DELIVERY SYSTEM
(FR) SYSTEME D'APPORT DE PROTEINES INFECTIEUSES
Abstract:
(EN) A virion expression system for a desired protein packaged in an envelope derived from a retrovirus useful in administering proteins which cross cell membranes in order to serve their function. Preferred virions are those that carry an RNA sequence that encodes cytokines or lymphokines, and includes IL-2, multiple drug resistance protein, and TNF.
(FR) L'invention concerne un système d'expression de virions pour une protéine désirée emballée dans une enveloppe dérivée d'un rétrovirus utile pour administrer des protéines qui traversent les membranes des cellules de manière à exercer leurs fonctions. Des virions préférés sont ceux qui transportent une séquence ARN qui code des cytokines ou des lymphokines, et qui comprend IL-2, une protéine de résistance à des médicaments multiples, et TNF.
Designated States: AU, CA, JP
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0497922CA2067821AU1991069566