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1. (WO1991006654) A METHOD OF VACCINE OR TOXOID PREPARATION AND IMMUNIZATION BY COLONIZATION WITH RECOMBINANT MICROORGANISMS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/006654 International Application No.: PCT/US1990/004988
Publication Date: 16.05.1991 International Filing Date: 30.08.1990
Chapter 2 Demand Filed: 18.03.1991
IPC:
A61K 38/00 (2006.01) ,A61K 39/00 (2006.01) ,C07K 14/035 (2006.01) ,C12N 15/74 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
01
DNA viruses
03
Herpetoviridae, e.g. pseudorabies virus
035
Herpes simplex virus I or II
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
74
Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
Applicants:
CEDARS-SINAI MEDICAL CENTER [US/US]; 8700 Beverly Boulevard Los Angeles, CA 90048, US
Inventors:
BRUNELL, Philip, Alfred; US
Agent:
BLOOMBERG, Coe, A. ; Lyon & Lyon 611 West Sixth Street 34th Floor Los Angeles, CA 90017, US
Priority Data:
430,49101.11.1989US
Title (EN) A METHOD OF VACCINE OR TOXOID PREPARATION AND IMMUNIZATION BY COLONIZATION WITH RECOMBINANT MICROORGANISMS
(FR) PROCEDE DE PREPARATION DE VACCINS OU D'AGENTS TOXIQUES ET D'IMMUNISATION CONTRE LES MALADIES PATHOGENES
Abstract:
(EN) A method of vaccine or toxoid preparation and immunization against pathogenic disease. An area of the body is colonized with indigenous microorganisms that have been transformed by recombinant DNA technology to express pathogenic antigens. The colonized transformant microorganisms will replicate and elicit an immune response to the pathogenic antigen, thereby protecting the individual from subsequent exposure to the intact pathogen.
(FR) On colonise une région du corps avec des microorganismes indigènes préalablement transformés par la technologie de l'ADN recombinant pour exprimer des antigènes pathogènes. Les microorganismes transformants colonisés subiront une réplication et pourront provoquer une réponse immunitaire à l'antigène pathogène, protégeant ainsi le patient d'une exposition ultérieure au pathogène intact.
Designated States: CA, JP
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0498804CA2072657