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1. (WO1991006650) C1 INHIBITOR MUTEINS AND USES THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/006650 International Application No.: PCT/US1990/006072
Publication Date: 16.05.1991 International Filing Date: 22.10.1990
Chapter 2 Demand Filed: 02.04.1991
IPC:
A61K 38/00 (2006.01) ,C07K 14/81 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
81
Protease inhibitors
Applicants:
CETUS CORPORATION [US/US]; 1400 Fifty-Third Street Emeryville, CA 94608, US
Inventors:
ELDERING, Eric; NL
AARDEN, Lucien; NL
Agent:
GIOTTA, Gregory, J.; Cetus Corporation 1400 Fifty-Third Street Emeryville, CA 94608, US
Priority Data:
428,20227.10.1989US
Title (EN) C1 INHIBITOR MUTEINS AND USES THEREOF
(FR) MUTEINES D'INHIBITEUR DE C1 ET LEURS UTILISATIONS
Abstract:
(EN) Compositions consisting of C1 inhibitor muteins having biological activity similar to C1 inhibitor, but with enhanced resistance to proteolytic cleavage thus rendering such muteins suitable as anti-inflammatory agents, preferably for the treatment or prevention of sepsis.
(FR) Composition consistant en des mutéines d'inhibiteur C1 ayant une activité biologique semblable à l'inhibiteur de C1, mais avec une plus grande résistance au clivage protéolytique, rendant ainsi ces mutéines utiles comme agents anti-inflammatoires, de préférence pour le traitement ou la prévention de la septicémie.
Designated States: AU, CA, JP
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0497833JPH05503001CA2071871AU1990066112