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1. (WO1991006641) ENHANCEMENT OF CELL GROWTH BY EXPRESSION OF A CLONED HEMOGLOBIN GENE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/006641 International Application No.: PCT/US1990/006083
Publication Date: 16.05.1991 International Filing Date: 26.10.1990
Chapter 2 Demand Filed: 30.05.1991
IPC:
C07K 14/805 (2006.01) ,C12N 1/38 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
795
Porphyrin- or corrin-ring-containing peptides
805
Haemoglobins; Myoglobins
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1
Micro-organisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving micro-organisms or compositions thereof; Processes of preparing or isolating a composition containing a micro-organism; Culture media therefor
38
Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
Applicants:
CALIFORNIA INSTITUTE OF TECHNOLOGY [US/US]; 629 South Grand Avenue Pasadena, CA 91105, US
Inventors:
BAILEY, James, E.; US
KHOSLA, Chaitan, S.; US
Agent:
SUYAT, Reginald, J. ; Heller, Ehrman, White & Mcauliffe 333 Bush Street San Francisco, CA 94104-2878, US
Priority Data:
429,09330.10.1989US
Title (EN) ENHANCEMENT OF CELL GROWTH BY EXPRESSION OF A CLONED HEMOGLOBIN GENE
(FR) AUGMENTATION DE LA CROISSANCE CELLULAIRE PAR EXPRESSION D'UN GENE D'HEMOGLOBINE CLONE
Abstract:
(EN) The invention related to a gene promoter/regulator (Region A in Fig. 1) which is useful in subjecting expression of protein or polypeptides in a host cell to selective regulation by external control. In particular, this regulation may be accomplished to different extends by the level of dissolved oxygen, presence of cAMP-CAP, and/or a complex nitrogen source in the culture or environment. The invention also relates to a method of improving production of proteins in a host by coproduction of hemoglobin in the host.
(FR) L'invention concerne un promoteur/régulateur de gènes (région A dans la Fig. 1) qui est utile pour soumettre l'expression d'une protéine ou de polypeptides dans une cellule hôte à une régulation sélective par commande extérieure. En particulier cette régulation peut s'effectuer à différents degrés en fonction du niveau d'oxygène dissous, de la présence de cAMP-CAP, et/ou d'une source d'azote complexe dans la culture ou l'environnement. L'invention concerne également un procédé d'amélioration de la production de protéines dans un hôte par coproduction d'hémoglobine dans l'hôte.
Designated States: AU, CA, JP
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
IL96143EP0500652JPH05503002CA2072149AU1990067104