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1. (WO1991006572) DIAGNOSIS OF GLOMERULONEPHRITIS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/006572 International Application No.: PCT/US1990/006277
Publication Date: 16.05.1991 International Filing Date: 29.10.1990
Chapter 2 Demand Filed: 28.05.1991
IPC:
C07K 16/18 (2006.01) ,C12N 9/64 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
48
acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
50
Proteinases
64
derived from animal tissue, e.g. rennin
Applicants:
THE GENERAL HOSPITAL CORPORATION [US/US]; Office of Technology Affairs 75 Blossom Street Boston, MA 02114, US
Inventors:
ARNAOUT, M., Amin; US
McCLUSKEY, Robert, T.; US
NILES, John, L.; US
Agent:
CLARK, Paul, T.; Fish & Richardson 225 Franklin Street Boston, MA 02110-2804, US
Priority Data:
428,28627.10.1989US
Title (EN) DIAGNOSIS OF GLOMERULONEPHRITIS
(FR) DIAGNOSTIC DE GLOMERULONEPHRITE
Abstract:
(EN) A purified protein (p29) capable of binding autoantibodies present in the sera of individuals suffering from Wegener's granulomatosis. The invention also features a monoclonal antibody against the p29 protein and methods of diagnosing Wegener's granulomatosis, pauci-immune necrotizing and/or crescentic glomerulonephritis, and other conditions associated with glomerulonephtritis.
(FR) Protéine purifiée (p29) capable de lier les autoanticorps présents dans les sérums d'individus souffrant de la granulomatose de Wegener. L'invention concerne également un anticorps monoclonal contre la protéine p29 ainsi que des procédés de diagnostic de la granulamatose de Wegener, de la glomérulonéphrite nécrosante et/ou maligne pauci-immune, ainsi que d'autres états associés à la glomérulonéphrite.
Designated States: AU, CA, JP
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0497897US5200319CA2071530AU1990067381