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1. (WO1991006571) A HUMAN T CELL REACTIVE FELINE PROTEIN (TRFP) ISOLATED FROM HOUSE DUST AND USES THEREFOR
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/006571 International Application No.: PCT/US1990/006548
Publication Date: 16.05.1991 International Filing Date: 02.11.1990
Chapter 2 Demand Filed: 27.05.1991
IPC:
A61K 38/00 (2006.01) ,A61K 39/35 (2006.01) ,C07K 14/47 (2006.01) ,C07K 16/18 (2006.01) ,C12N 15/62 (2006.01) ,G01N 33/50 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
35
Allergens
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
47
from mammals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
62
DNA sequences coding for fusion proteins
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
Applicants:
IMMULOGIC PHARMACEUTICAL CORPORATION [US/US]; One Kendall Square, Building 600 Cambridge, MA 02139, US
Inventors:
GEFTER, Malcolm, L.; US
GARMAN, Richard, D.; US
GREENSTEIN, Julia, L.; US
KUO, Mei-chang; US
ROGERS, Bruce, L.; US
BRAUER, Andrew, W.; US
Agent:
GRANAHAN, Patricia ; Hamilton, Brook, Smith & Reynolds Two Militia Drive Lexington, MA 02173, US
Priority Data:
431,56503.11.1989US
Title (EN) A HUMAN T CELL REACTIVE FELINE PROTEIN (TRFP) ISOLATED FROM HOUSE DUST AND USES THEREFOR
(FR) PROTEINE DE FELIN REAGISSANT AVEC DES LYMPHOCYTES T HUMAINS (PFRL), ISOLEE A PARTIR DE POUSSIERES MENAGERES
Abstract:
(EN) A substantially pure, covalently linked human T cell reactive feline protein (TRFP) of approximately 40,000 MW has been isolated from vacuum bag extract obtained by affinity purification of house dust collected from several homes with cats; DNA encoding all or a portion of the TRFP or peptide; compositions containing such a protein or peptide or portions thereof; and antibodies reactive with the TRFP or peptide are disclosed. Also disclosed are recombinant TRFP or peptide; modified or mutated TRFP peptides; their use for diagnostic or therapeutic purposes.
(FR) On a isolé une protéine de félin réagissant avec des lymphocytes T humains (PFRL) à liaison covalente, sensiblement purs, d'approximativement 40000 MW, à partir d'un extrait de sac à vide obtenu par purification par affinité de poussières ménagères collectées dans plusieurs maisons où vivent des chats; de l'ADN codant tout ou partie de la protéine ou du peptide FRL; des compositions contenant ladite protéine ou ledit peptide, ou des parties de ceux-ci; ainsi que des anticorps réagissant avec la protéine ou le peptide FRL sont décrits. Sont également décrits la protéine ou le peptide FRL recombinées; des protéines ou des peptides FRL modifiés ou mutés; leur emploi à des fins de diagnostic ou de thérapie.
Designated States: AU, CA, DK, FI, JP, NO
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
FI921979NO19921697EP0500785US20040057959US7482008JP3251012
JPH05502445CA2073045DE000069033949AU1990067330DK0500785