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1. (WO1991006569) IODOTHYRONINE POLYMERS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/006569 International Application No.: PCT/US1990/006213
Publication Date: 16.05.1991 International Filing Date: 31.10.1990
Chapter 2 Demand Filed: 21.05.1991
IPC:
A61K 38/00 (2006.01) ,C07D 263/44 (2006.01) ,C07K 14/575 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
263
Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
02
not condensed with other rings
30
having two or three double bonds between ring members or between ring members and non-ring members
34
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
44
Two oxygen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
575
Hormones
Applicants:
BOOTS PHARMACEUTICALS INC. [US/US]; 300 Tri State International Centre Lincolnshire, IL 60069-4415, US (AllExceptUS)
LATHAM, Keith, Roger [US/US]; US (UsOnly)
LATHAM, Vincent, Ernest [US/US]; US (UsOnly)
Inventors:
LATHAM, Keith, Roger; US
LATHAM, Vincent, Ernest; US
Agent:
MURRAY, Robert, B.; Armstrong, Nikaido, Marmelstein, Kubovcik & Murray Suite 1000 1725 K Street, N.W. Washington, DC 20006, US
Priority Data:
430,99003.11.1989US
Title (EN) IODOTHYRONINE POLYMERS
(FR) POLYMERES D'IODOTHYRONINE
Abstract:
(EN) Iodothyronine polymers having a plurality of recurring units of formula (I), in which A is iodo and B, C, and D are independently H or iodo are described. Polymers in which A and C are iodo and B and D are independently H or iodo and in which substantially all of the recurring units are L-stereoisomers, have utility in treating thyroid hormone deficiencies. The polymers are preferably prepared by polymerization of N-carboxyanhydrides of formula (III).
(FR) Des polymères d'iodothyronine possédant une pluralité d'unités récurrentes dont la formula est (I), où A est iodo et B, C, et D sont indépendamment iodo ou H. Des polymères dans lesquels A et C sont iodo et B et D sont indépendamment H ou iodo, et dans lesquels sensiblement toutes les unités récurrentes sont des L-stéréoisomères, sont utiles au traitement de la déficience d'hormones thyroïdiennes. De préférence, on prépare les polymères par la polymérisation des N-carboxyanhydrides dont la formule est (III).
Designated States: AT, AU, BG, BR, CA, CH, DE, DK, ES, FI, GB, HU, JP, KR, LU, NL, NO, RO, SE, SU, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CA2072613AU1990066397