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1. (WO1991006559) USE OF POLYMERIZED IMMUNOGLOBULIN TO REDUCE THE INCIDENCE OF FALSE-POSITIVE RESPONSES IN IMMUNOASSAYS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/006559 International Application No.: PCT/US1990/005943
Publication Date: 16.05.1991 International Filing Date: 22.10.1990
Chapter 2 Demand Filed: 08.05.1991
IPC:
C07K 16/00 (2006.01) ,G01N 33/53 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
Applicants:
E.I. DU PONT DE NEMOURS AND COMPANY [US/US]; 1007 Market Street Wilmington, DE 19898, US
Inventors:
GORMAN, Eileen, G.; US
HUA, David, Ta-Chih; US
TYSON, Richard, Lee; US
VICKERY, Deborah, K.; US
WANG, Chi-Chin; US
Agent:
FATO, Gildo, E. ; E.I. du Pont de Nemours and Company Legal Department 1007 Market Street Wilmington, DE 19898, US
Priority Data:
426,00124.10.1989US
Title (EN) USE OF POLYMERIZED IMMUNOGLOBULIN TO REDUCE THE INCIDENCE OF FALSE-POSITIVE RESPONSES IN IMMUNOASSAYS
(FR) EMPLOI D'IMMUNOGLOBULINE POLYMERISEE AFIN DE REDUIRE LA FREQUENCE DE REACTIONS POSITIVES FAUSSES DANS DES IMMUNOANALYSES
Abstract:
(EN) The present invention relates to a method to reduce false positive results in immunoassays. The method uses polymerized immunoglobulin to overcome binding which is commonly referred to as non-specific binding. The falsely elevated signal generated in the presence of human serum in assays for infectious disease markers, cancer related antigens and peptide hormones is reduced in assays performed in the presence of the polymerized immunoglobulin. The polymerized immunoglobulin can be prepared using different methods of polymerization.
(FR) Procédé de réduction de résultats positifs faux dans des immunoanalyses. Le procédé utilise l'immunoglobuline polymérisée afin de maîtriser la liaison communément appelée liaison non spécifique. Le signal faussement élevé produit en présence de sérum humain dans des analyses de détection de marqueurs de maladies infectieuses, d'antigènes et d'hormones peptidiques apparentés au cancer, est réduit dans des analyses effectuées en présence de l'immunoglobuline polymérisée. On peut préparer l'immunoglobuline polymérisée selon différents procédés de polymérisation.
Designated States: AU, CA, FI, JP, NO
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1990067107