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1. (WO1991006540) 1,4-BIS(ALKYLAMINO)-2,3-DIAZA-ANTHRACENE-9,10-DIONES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/006540 International Application No.: PCT/EP1990/001794
Publication Date: 16.05.1991 International Filing Date: 23.10.1990
Chapter 2 Demand Filed: 19.04.1991
IPC:
C07D 237/26 (2006.01) ,C07D 403/06 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
237
Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
26
condensed with carbocyclic rings or ring systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
06
linked by a carbon chain containing only aliphatic carbon atoms
Applicants:
BOEHRINGER BIOCHEMIA ROBIN S.P.A. [IT/IT]; Via S.Uguzzone, 5 I-20126 Milano, IT (AllExceptUS)
GANDOLFI, Carmelo, A. [IT/IT]; IT (UsOnly)
JOHNSON, Francis [IT/IT]; IT (UsOnly)
MENTA, Ernesto [IT/IT]; IT (UsOnly)
SPINELLI, Silvano [IT/IT]; IT (UsOnly)
TOGNELLA, Sergio [IT/IT]; IT (UsOnly)
Inventors:
GANDOLFI, Carmelo, A.; IT
JOHNSON, Francis; IT
MENTA, Ernesto; IT
SPINELLI, Silvano; IT
TOGNELLA, Sergio; IT
Agent:
MINOJA, Fabrizio; Studio Consulenza Brevettuale Via Rossini, 8 I-20122 Milano, IT
Priority Data:
22175 A/8927.10.1989IT
Title (EN) 1,4-BIS(ALKYLAMINO)-2,3-DIAZA-ANTHRACENE-9,10-DIONES
(FR) 1,4-BIS(ALKYLAMINO)-2,3-DIAZA-ANTHRACENE-9,10-DIONES
Abstract:
(EN) Compounds of formula (I) are described, wherein R1 and R2, that can be the same or different, are hydrogen or acyl groups; R3 and R4, that can be the same or different, are hydrogen or optionally substituted alkyl groups. The compounds of formula (I) are prepared by oxidation of the compounds of formula (II), wherein the groups R'1, R'2, R'3 and R'4 have the same meanings as R1, R2, R3 and R4 or groups convertible to the latter. The compounds of formula (I) have remarkable antitumor activity.
(FR) On décrit des composés dont la formule est (I), où R1 et R2, qui peuvent être les mêmes ou différents, sont des groupes hydrogène ou acyle; R3 et R4, qui peuvent être les mêmes ou différents, sont des groupes hydrogène ou éventuellement des groupes alkyle substitués. Les composés dont la formule est (I) peuvent être preparés par l'oxydation des composés dont la formule est (II), où les groupes R'1, R'2, R'3 et R'4 ont les mêmes significations que R1, R2, R3 et R4 ou peuvent être convertis en ceux-ci. Les composés de la formule (I) présentent une activité anti-tumorale remarquable.
Designated States: AU, BB, BG, BR, CA, FI, HU, JP, KP, KR, LK, MC, MG, MW, NO, RO, SD, SU, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CM, GA, ML, MR, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0497809US5162320JPH05504124DE000069020576AU1990065481