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1. (WO1991006309) METHOD OF IN VIVO DELIVERY OF FUNCTIONING FOREIGN GENES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/006309 International Application No.: PCT/US1990/005993
Publication Date: 16.05.1991 International Filing Date: 18.10.1990
IPC:
A61K 9/127 (2006.01) ,A61K 47/48 (2006.01) ,A61K 48/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
127
Liposomes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Applicants:
VANDERBILT UNIVERSITY [US/US]; 305 Kirkland Hall Nashville, TN 37240, US
Inventors:
BRIGHAM, Kenneth, L.; US
Agent:
KOHN, Kenneth, I.; Tilton, Fallon, Lungmus & Chestnut P.O. Box 4390 Troy, MI 48099, US
Priority Data:
431,55203.11.1989US
Title (EN) METHOD OF IN VIVO DELIVERY OF FUNCTIONING FOREIGN GENES
(FR) PROCEDE D'ADMINISTRATION IN VIVO DE GENES ETRANGERS FONCTIONNELS
Abstract:
(EN) A method of expressing a foreign gene in cells of a mammalian organ in vivo includes the step of injecting genetic material capable of inducing desired gene products into a mammal. The genetic material is complexed to cationic liposome carriers. The genetic material is lipofected into cells of the mammalian organ. Gene expression and cellular function of the genetic material are activated to produce the desired foreign products in the cells of the organ.
(FR) Un procédé d'expression d'un gène étranger dans des cellules d'un organe mammifère in vivo, comprend l'étape consistant à injecter une matière génétique capable d'induire des produits de gènes voulus dans un mammifère. La matière génétique est transformée en complexe afin d'obtenir des supports de liposomes cationiques. La matière génétique est transmise à l'aide de liposomes dans des cellules de l'organe mammifère. On active l'expression des gènes ainsi que la fonction cellulaire de la matière génétique afin de produire les produits étrangers voulus dans les cellules de l'organe.
Designated States: AU, CA, JP
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0452457JP3056782CA2044593AU1990066456DK0452457