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1. (WO1991006297) (N-PHTHALIMIDOALKYL) PIPERIDINES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/006297 International Application No.: PCT/US1990/006102
Publication Date: 16.05.1991 International Filing Date: 29.10.1990
Chapter 2 Demand Filed: 25.04.1991
IPC:
C07D 401/04 (2006.01) ,C07D 401/06 (2006.01) ,C07D 401/14 (2006.01) ,C07D 409/14 (2006.01) ,C07D 491/18 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
06
linked by a carbon chain containing only aliphatic carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
409
Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
491
Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
12
in which the condensed system contains three hetero rings
18
Bridged systems
Applicants:
THE DU PONT MERCK PHARMACEUTICAL COMPANY [US/US]; Barley Mill Plaza, Building 25 Wilmington, DE 19805, US
Inventors:
CIGANEK, Engelbert; US
TAM, Sang, William; US
WRIGHT, Ann, Sorrentino; US
Agent:
HORN, Margaret, A. ; E.I. du Pont de Nemours and Company Legal/Patent Records Center 1007 Market Street Wilmington, DE 19898, US
Priority Data:
428,09727.10.1989US
602,02423.10.1990US
Title (EN) (N-PHTHALIMIDOALKYL) PIPERIDINES
(FR) (N-PHTHALIMIDOALKYLE)PIPERIDINES
Abstract:
(EN) There are described novel (N-phthalimidoalkyl) piperidine compounds which exhibit selective sigma-receptor antagonism and therefore are useful in the treatment of physiological or drug induced psychosis and dyskinesia in a mammal. Also described are pharmaceutical compositions containing sigma selective compounds and methods of using these compositions for treating physiological or drug induced psychosis or dyskinesia in a mammal. Further provided are methods for preparing the compounds of this invention.
(FR) Nouveau composé (N-phthalimidoalkyle) pipéridine présentant un antagonisme de sigma-récepteur sélectif et par conséquent ayant une utilité dans le traitement de psychoses physiologiques ou induites par médicaments et de la dyskinésie chez un mammifère. L'invention concerne également des compositions pharmaceutiques contenant des composés sigma-sélectifs et des procédés d'utilisation de ces compositions pour le traitement de psychoses physiologiques ou induites par médicaments ou de la dyskinésie chez un mammifère. Sont également décrits des procédés de préparation des composés de cette invention.
Designated States: AU, CA, FI, HU, JP, KR, NO, SU
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
FI921856NO19921594EP0497843JPH06504980CA2069318KR1019927002347
AU1990066265