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1. (WO1991006293) COMPOSITION CONTAINING 2,3-BUTANEDIONE MONOXIME AND METHOD FOR REVERSIBLY ARRESTING MUSCLE ACTIVITY
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/006293 International Application No.: PCT/US1990/006241
Publication Date: 16.05.1991 International Filing Date: 01.11.1990
Chapter 2 Demand Filed: 31.05.1991
IPC:
A01N 1/02 (2006.01) ,A61K 31/15 (2006.01) ,A61K 38/28 (2006.01)
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
1
Preservation of bodies of humans or animals, or parts thereof
02
Preservation of living parts
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
13
Amines, e.g. amantadine
15
Oximes (CN-O-); Hydrazines (N-N); Hydrazones (N-N)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
22
Hormones
28
Insulins
Applicants:
UNIVERSITY OF VERMONT AND STATE AGRICULTURAL COLLEGE [US/US]; Burlington, VT 05405, US
Inventors:
MULIERI, Louis, A.; US
HASENFUSS, Gerd; DE
ALPERT, Norman, R.; US
Agent:
DeCONTI, Giulio, A., Jr. ; Lahive & Cockfield 60 State Street Boston, MA 02109, US
Priority Data:
430,61401.11.1989US
Title (EN) COMPOSITION CONTAINING 2,3-BUTANEDIONE MONOXIME AND METHOD FOR REVERSIBLY ARRESTING MUSCLE ACTIVITY
(FR) PROCEDE ET COMPOSITION SERVANT A ARRETER DE FAÇON REVERSIBLE L'ACTIVITE D'UN MUSCLE
Abstract:
(EN) A method of reversibly arresting muscle activity (e.g. cardioplegia) by administering a reagent such as 2,3-butanedione monoxime which selectively and reversibly blocks the interaction of the contractile proteins actin and myosin is described. Compositions for arresting muscle activity are also described.
(FR) Le procédé décrit, qui sert à arrêter de façon réversible l'activité d'un muscle (par exemple pour obtenir une cardioplégie), consiste à administrer un réactif, tel que du monoxime de 2,3-butanedione, qui bloque de façon sélective et réversible l'interaction des protéines contractiles actine et myosine. Des compositions servant à arrêter l'activité d'un muscle sont également décrites.
Designated States: CA, JP
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)