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1. (WO1991006287) PROTEIN MICROSPHERES AND METHODS OF USING THEM
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/006287 International Application No.: PCT/US1990/006433
Publication Date: 16.05.1991 International Filing Date: 06.11.1990
Chapter 2 Demand Filed: 04.06.1991
IPC:
A01N 25/28 (2006.01) ,A61K 9/16 (2006.01) ,B01J 13/12 (2006.01)
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
25
Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
26
in coated particulate form
28
Microcapsules
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
14
Particulate form, e.g. powders
16
Agglomerates; Granulates; Microbeadlets
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
J
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS, COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
13
Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
02
Making microcapsules or microballoons
06
by phase separation
12
removing solvent from the wall-forming material solution
Applicants:
ENZYTECH, INC. [US/US]; 64 Sidney Street Cambridge, MA 02139, US
Inventors:
BERSTEIN, Howard; US
MORREL, Eric; US
MATHIOWITZ, Edith; US
SCHWALLER, Kirsten; US
BECK, Thomas, R.; US
Agent:
PABST, Patrea, L. ; Kilpatrick & Cody 100 Peachtree Street Suite 3100 Atlanta, GA 30303, US
Priority Data:
432,78906.11.1989US
557,62024.07.1990US
Title (EN) PROTEIN MICROSPHERES AND METHODS OF USING THEM
(FR) MICROSPHERES DE PROTEINES ET LEURS PROCEDES D'UTILISATION
Abstract:
(EN) Biodegradable, protein microspheres for $i(in vivo) release of a biologically active agent, as well as agricultural and environmental applications. The microspheres can be administered orally, intravenously, or subcutaneously for subsequent release. By selecting particular size ranges and the specific protein used to form the microsphere, it is possible to target the microspheres to cell types such as macrophages, or to effect localized absorption of the microspheres to regions such as the mucosal membranes of the mouth, gastrointestinal tract, or urogenital areas. Larger forms of the microspheres can also be made using standard techniques of the desirable degradation properties.
(FR) Microsphères biodégradables de protéines pour l'administration $i(in vivo) d'agents biologiquement actifs, ainsi que pour des applications agricoles et de protection de l'environnement. On peut administrer les microsphères oralement, par voie intraveineuse ou sous-cutanée, à des fins de libération ultérieure. Par une sélection approprié des dimensions des microsphères et de la protéine spécifique utilisée pour former les microsphères. il est possible de diriger les microsphères vers des types de cellules tels que les microphages, ou d'obtenir une absorption localisée des microsphères dans des régions telles que les muqueuses de la bouche, des voies gastrointestinales ou des zones urogénitales. On peut également produire des microsphères de plus grandes dimensions par des techniques standard, afin d'obtenir les propriétés de dégradation voulues.
Designated States: AU, CA, JP
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0550436CA2071867AU1990067360