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1. (WO1991006282) SMALL PARTICLE DRUG COMPOSITIONS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/006282 International Application No.: PCT/GB1990/001676
Publication Date: 16.05.1991 International Filing Date: 01.11.1990
Chapter 2 Demand Filed: 01.05.1991
IPC:
A61K 9/00 (2006.01) ,A61K 9/16 (2006.01) ,A61K 9/51 (2006.01) ,A61K 47/24 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
14
Particulate form, e.g. powders
16
Agglomerates; Granulates; Microbeadlets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
50
Microcapsules
51
Nanocapsules
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
24
containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen or sulfur
Applicants:
DANBIOSYST UK LIMITED [GB/GB]; 6 William Lee Building Highfields Science Park Nottingham NG7 2RQ, GB (AllExceptUS)
ILLUM, Lisbeth [DK/GB]; GB (UsOnly)
Inventors:
ILLUM, Lisbeth; GB
Agent:
BASSETT, Richard, S.; Eric Potter Clarkson St Mary's Court St Mary's Gate Nottingham NG1 1LE, GB
Priority Data:
8924935.304.11.1989GB
Title (EN) SMALL PARTICLE DRUG COMPOSITIONS
(FR) COMPOSITIONS PHARMACOLOGIQUES A PARTICULES DE TAILLE REDUITE
Abstract:
(EN) A drug delivery composition for intranasal delivery comprises a plurality of bioadhesive microspheres and active drug associated with each microsphere, at least 90 wt % of the microspheres having a diameter in the range 0.1 $g(m)m to 10 $g(m)m. The microspheres may be of starch, gelatin, dextran, collagen or albumin. Suitable drugs include peptides, such as insulin, and antigenic vaccine ingredients. The composition may additionally comprise an absorption enhancer. The microspheres are administered to the nasal cavity by a means such that the product of the square of the microsphere diameter and the flow rate is greater than 2000 $g(m)m2 litres/min.
(FR) Une composition pharmacologique libérable destinée à une administration nasale comprend une pluralité de microsphères, ainsi qu'un médicament actif associé à chaque microsphère. Au moins 90 % en poids des microsphères possède un diamètre compris entre 0,1 $g(m)m et 10 $g(m)m. Les microsphères peuvent être constituées d'amidon, de gélatine, de dextrane, de collagène ou d'albumine. Des médicaments appropriés comprennent les peptides, comme l'insuline, et des ingrédients de vaccins antigéniques. La composition peut en outre comporter un promoteur d'absorption. Les microsphères sont administrées à la cavité nasale par un moyen qui assure que le produit du carré du diamètre des microsphères et du débit est supérieur à 2000 $g(m)m litres/min.
Designated States: CA, JP, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
ES2112253EP0500594US5707644US5804212JPH05501408CA2060176
DE000069031950GB2237510DK0500594