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1. (WO1991005860) NON-INFECTIOUS HIV-1 PARTICLES AND USES THEREFOR
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/005860 International Application No.: PCT/US1990/005932
Publication Date: 02.05.1991 International Filing Date: 16.10.1990
Chapter 2 Demand Filed: 15.05.1991
IPC:
A61K 39/00 (2006.01) ,A61K 39/21 (2006.01) ,C12N 7/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
12
Viral antigens
21
Retroviridae, e.g. equine infectious anemia virus
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7
Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
Applicants:
WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH [US/US]; Nine Cambridge Center Cambridge, MA 02142, US
Inventors:
YOUNG, Richard, A.; US
BALTIMORE, David; US
ALDOVINI, Anna; US
TRONO, Didier; US
FEINBERG, Mark, B.; US
Agent:
GRANAHAN, Patricia ; Hamilton, Brook, Smith & Reynolds Two Militia Drive Lexington, MA 02173, US
Priority Data:
421,81716.10.1989US
Title (EN) NON-INFECTIOUS HIV-1 PARTICLES AND USES THEREFOR
(FR) PARTICULES NON INFECTIEUSES DE VIH-1 ET LEURS EMPLOIS
Abstract:
(EN) HIV-1 mutant constructs which include a mutation in a nucleotide sequence which is present in wild-type HIV-1, in which it is critical in packaging HIV-1, as well as HIV-1 mutant expression products and HIV mutant viral particles, which are non-infectious. Vaccines which are HIV-1 mutant constructs or HIV-1 mutant expression products, as well as a method if immunizing an individual, comprising administering the vaccine in an appropriate amount.
(FR) Structures mutantes de VIH-1 comprenant une mutation dans une séquence de nucléotides présente dans le VIH-1 de type sauvage, dans lesquelles elle est critique dans l'encapsulation du VIH-1, ainsi que des produits d'expression mutants du VIH-1 et des particules virales mutantes du VIH, lesquelles sont non infectieuses. L'invention concerne également des vaccins qui sont des structures mutantes de VIH-1 ou des produits d'expression mutants du VIH-1, ainsi qu'un procédé d'immunisation d'un individu consistant à administrer le vaccin en une dose appropriée.
Designated States: CA, JP
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0496794JPH05501201CA2067778