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1. (WO1991005853) GROWTH HORMONE ANTAGONISTS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/005853 International Application No.: PCT/US1990/005874
Publication Date: 02.05.1991 International Filing Date: 12.10.1990
Chapter 2 Demand Filed: 10.05.1991
IPC:
A61K 38/00 (2006.01) ,C07K 14/61 (2006.01) ,C12N 15/85 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
575
Hormones
61
Growth hormone (GH) (Somatotropin)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
Applicants:
OHIO UNIVERSITY [US/US]; Edison Animal Biotechnology Center Wilson Hall/West Green Ohio University Athens, OH 45701, US (AllExceptUS)
KOPCHICK, John, J. [US/US]; US (UsOnly)
CHEN, Wen, Y. [CN/US]; US (UsOnly)
Inventors:
KOPCHICK, John, J.; US
CHEN, Wen, Y.; US
Agent:
COOPER, Iver, P.; Browdy and Neimark 419 7th Street, N.W. Suite 300 Washington, DC 20004, US
Priority Data:
419,56112.10.1989US
Title (EN) GROWTH HORMONE ANTAGONISTS
(FR) ANTAGONISTES D'HORMONES DE CROISSANCE
Abstract:
(EN) The present invention relates to growth inhibitory antagonists of bovine growth hormone obtained by mutation of the third alpha helix of that protein. These novel hormones may be administered exogenously to animals, or transgenic animals may be made that express the antagonist and thereby exhibited a reduced growth phenotype.
(FR) Antagonistes inhibiteurs de croissance d'hormone de croissance bovine, obtenus par mutation de la troisième hélice alpha de cette protéine. On peut administrer ces nouvelles hormones à des animaux par voie exogène, ou l'on peut produire des animaux transgénique exprimant l'antagoniste et présentant ainsi un phénotype de croissance réduit.
Designated States: AU, CA, JP, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0556171US5958879US6583115US6787336JP3789928JPH05505518
CA2067136AU1991068783