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1. (WO1991005806) INTERFACIAL CONDENSATION OF BIOACTIVE COMPOUNDS AND THE SITE-SPECIFIC COMPOUNDS AND CONJUGATES THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/005806 International Application No.: PCT/US1990/005544
Publication Date: 02.05.1991 International Filing Date: 02.10.1990
Chapter 2 Demand Filed: 19.04.1991
IPC:
A61K 47/48 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
Applicants:
BRUNSWICK CORPORATION [US/US]; One Brunswick Plaza Skokie, IL 60077, US
Inventors:
WRASIDLO, Wolfgang, J.; US
Agent:
WALDRON, James, S.; Waldron & Associates 2120 L Street, N.W. Suite 200 Washington, DC 20037, US
Priority Data:
419,33710.10.1989US
Title (EN) INTERFACIAL CONDENSATION OF BIOACTIVE COMPOUNDS AND THE SITE-SPECIFIC COMPOUNDS AND CONJUGATES THEREOF
(FR) CONDENSATION INTERFACIALE DE COMPOSES BIOACTIFS AINSI QUE LEURS COMPOSES ET CONJUGUES SPECIFIQUES A UN SITE
Abstract:
(EN) This invention provides a method of preparing conjugates of bioactive compounds and site-specific compounds in which covalent bonding between the compounds is effected by interfacial condensation while protecting the active binding sites from the condensation reaction. This provides very high yields of the bioactive, site-specific conjugate, the products are homogeneous and it provides novel conjugate products. It is of particular advantage for monoclonal antibodies conjugated with cytotoxic agents.
(FR) Procédé de préparation de conjugués de composés bioactifs et de composés spécifiques à un site dans lequel la liaison covalente entre les composés est effectuée par condensation interfaciale, tout en protégeant les sites de liaison actifs de la réaction de condensation. Le procédé permet d'obtenir des rendements élevés du conjugué bioactif, spécifique à un site, des produits homogènes, ainsi que des nouveaux produits conjugués. Le procédé présente un avantage particulier pour les anticorps monoclonaux conjugués à des agents cytotoxiques.
Designated States: AU, CA, JP
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0494998JPH05501259CA2067210AU1990067108