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1. (WO1991005783) HETEROCYCLIC COMPOUNDS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/005783 International Application No.: PCT/GB1990/001561
Publication Date: 02.05.1991 International Filing Date: 10.10.1990
Chapter 2 Demand Filed: 01.03.1991
IPC:
C07D 451/04 (2006.01) ,C07D 451/14 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
451
Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.02,4] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
02
containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.02,4] nonane ring systems, e.g. tropane; Cyclic acetals thereof
04
with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.02,4] nonane ring system
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
451
Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.02,4] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
14
containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
Applicants:
JOHN WYETH & BROTHER LIMITED [GB/GB]; Huntercombe Lane South Taplow Maidenhead Berkshire SL6 0PH, GB
Inventors:
WARD, Terence, James; GB
WHITE, Janet, Christine; GB
Agent:
BROWN, Keith, John, Symons ; Wyeth Laboratories Huntercombe Lane South Taplow, Maidenhead Berkshire SL6 0PH, GB
Priority Data:
8923209.414.10.1989GB
9010085.004.05.1990GB
Title (EN) HETEROCYCLIC COMPOUNDS
(FR) COMPOSES HETEROCYCLIQUES
Abstract:
(EN) Compounds of formula (I), wherein R1 is hydrogen or one or more specified substituents, X is -O- or -NR2- where R2 is lower alkyl, lower alkenyl, lower alkynyl, aryl or specified substituted lower alkyl or R2 represents a group -Z- which is connected to the 8-position of the aromatic ring so as to form a heterocyclic ring of 5 to 7 ring members, Y is O or NR3 where R3 is hydrogen or lower alkyl, and B is a saturated azabicyclic ring (e.g. tropanyl or quinuclinidyl) or a N-oxide thereof and their acid addition salts are 5-HT3 antagonists which may be used in, for example, the treatment of neuro-psychiatric disorders.
(FR) Composés de la formule (I) dans laquelle R1 est de l'hydrogène ou l'un ou plusieurs subsituants spécifiés; X est -O- ou -NR2- dans lequel R2 est un alkyle inférieur, un alkényle inférieur, un alkynyle inférieur, un aryle ou un alkyle inférieur substitué spécifié ou R2 représente un groupe -Z- relié à la position 8 de la chaîne aromatique de manière à former une chaîne hétérocyclique comportant entre 5 et 7 anneaux; Y est O ou NR3, dans lequel R3 est de l'hydrogène ou un alkyle inférieur, et B est une chaîne azabicyclique saturée (par exemple tropanyle ou quinuclidinyle) ou son N-oxyde. Ces composés et leurs sels d'addition d'acide sont des antagonistes de 5-HT3 qui peuvent être utilisés, par exemple, dans le traitement des troubles neuro-psychiatriques.
Designated States: AU, CA, FI, HU, JP, KR
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
FI921560EP0494978CA2066640KR1019927003585AU1990066210