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1. (WO1991005770) POTENTIAL ANTICANCER AGENTS DERIVED FROM ACRIDINE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/005770 International Application No.: PCT/US1990/005958
Publication Date: 02.05.1991 International Filing Date: 17.10.1990
Chapter 2 Demand Filed: 17.05.1991
IPC:
C07C 229/58 (2006.01) ,C07D 219/04 (2006.01) ,C07D 219/06 (2006.01) ,C07D 219/10 (2006.01) ,C07D 295/192 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
229
Compounds containing amino and carboxyl groups bound to the same carbon skeleton
52
having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
54
with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
56
with amino and carboxyl groups bound in ortho- position
58
having the nitrogen atom of at least one of the amino groups further bound to a carbon atom of a six-membered aromatic ring, e.g. N-phenyl-anthranilic acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
219
Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
04
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
219
Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
04
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
06
Oxygen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
219
Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
04
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
08
Nitrogen atoms
10
attached in position 9
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
295
Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
16
acylated on ring nitrogen atoms
18
by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
182
Radicals derived from carboxylic acids
192
from aromatic carboxylic acids
Applicants:
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH [US/US]; 1275 York Avenue New York, NY 10021, US
Inventors:
WATANABE, Kyoichi, A.; US
TAKAHASHI, Kiyobumi; JP
Agent:
WHITE, John, P.; Cooper & Dunham 30 Rockefeller Plaza New York, NY 10112, US
Priority Data:
422,62917.10.1989US
Title (EN) POTENTIAL ANTICANCER AGENTS DERIVED FROM ACRIDINE
(FR) AGENTS ANTI-CANCEREUX POTENTIELS DERIVES DE L'ACRIDINE
Abstract:
(EN) The compounds of the subject invention can be represented by formula (I), wherein each of R1, R2, R3, R4 are the same or different and are hydrogen (H), or a lower alkyl group of from about 1-4 carbon atoms, or a lower alkoxy group of from about 1-4 carbon atoms. R is a substituted aniline ($g(a)), wherein one of R5, R6, R7 is an alkanol having the formula -(CH2)nOH, n = 1-4, or its carbamate ester having the formula -(CH2)nOCONR'R'', n = 1-4, and wherein R' and R'' are the same or different lower alkyl groups of from about 1 to 4 carbon atoms, one of R' and R'' may be hydrogen (H), and the remaining groups are hydrogen. Additionally, the subject invention provides methods for synthesizing the above-identified compounds, physiologically acceptable compositions containing these compounds and methods for using these compounds to inhibit the growth of tumor cells.
(FR) Les composés décrits peuvent être représentés par la formule (I), où: R1, R2, R3, R4 sont chacun identiques ou différents et représentent l'hydrogène (H) ou un groupe alkyle inférieur d'environ 1 à 4 atomes de carbone ou un groupe alkoxy inférieur d'environ 1 à 4 atomes de carbone; R représente une aniline substituée représentée par la formule ($g(a)), où l'un des éléments R5, R6, R7 représente un alkanol de formule -(CH2)nOH, et n est égal à un nombre compris entre 1 et 4, ou son ester de carbamate de formule -(CH2)nOCONR'R'', et n est égal à un nombre compris entre 1 et 4, et où R'et R'' représentent des groupes alkyle inférieurs identiques ou différents d'environ 1 à 4 atomes de carbone, l'un des éléments R' et R'' pouvant représentés l'hydrogène (H) et les groupes restants représentant l'hydrogène. L'invention se rapporte en outre à des procédés de synthèse de ces composés, à des compositions physiologiquement acceptables contenant ces composés et à des procédés d'utilisation de ces composés en vue d'inhiber la croissance de cellules tumorales.
Designated States: AU, CA, HU, JP, KR, SU
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1990066260