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1. (WO1991005762) MULTI-SITE METAL CHELATING AGENTS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/005762 International Application No.: PCT/EP1990/001792
Publication Date: 02.05.1991 International Filing Date: 20.10.1990
Chapter 2 Demand Filed: 24.12.1990
IPC:
A61K 49/06 (2006.01) ,C07C 237/06 (2006.01) ,C07C 237/10 (2006.01) ,C07C 237/12 (2006.01) ,C07D 241/06 (2006.01) ,C07D 257/02 (2006.01) ,C07D 295/185 (2006.01) ,C07F 19/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
06
Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
237
Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
02
having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
04
the carbon skeleton being acyclic and saturated
06
having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
237
Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
02
having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
04
the carbon skeleton being acyclic and saturated
10
having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
237
Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
02
having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
04
the carbon skeleton being acyclic and saturated
12
having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
241
Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
02
not condensed with other rings
06
having one or two double bonds between ring members or between ring members and non-ring members
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
257
Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
02
not condensed with other rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
295
Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
16
acylated on ring nitrogen atoms
18
by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
182
Radicals derived from carboxylic acids
185
from aliphatic carboxylic acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
19
Metal compounds according to more than one of main groups C07F1/-C07F17/110
Applicants:
COCKBAIN, Julian, Roderick, Michaelson [GB/GB]; GB (GB)
SALUTAR, INC. [US/US]; 428 Oakmead Parkway Sunnyvale, CA 94086, US (AllExceptUS)
LOVE, David [US/US]; US (UsOnly)
DOW, William, C. [US/US]; US (UsOnly)
HIMMELSBACH, Richard, J. [US/US]; US (UsOnly)
WATSON, Alan, D. [US/US]; US (UsOnly)
ROCKLAGE, Scott, M. [US/US]; US (UsOnly)
Inventors:
LOVE, David; US
DOW, William, C.; US
HIMMELSBACH, Richard, J.; US
WATSON, Alan, D.; US
ROCKLAGE, Scott, M.; US
Common
Representative:
COCKBAIN, Julian, Roderick, Michaelson ; Frank B. Dehn & Co. Imperial House 15-19 Kingsway London WC2B 6UZ, GB
Priority Data:
8923843.023.10.1989GB
9001247.719.01.1990GB
Title (EN) MULTI-SITE METAL CHELATING AGENTS
(FR) AGENTS CHELATEURS METALLIQUES MULTI-SITES
Abstract:
(EN) There are disclosed polychelant compounds, that is multi-site metal chelating agents, and chelates formed therewith. The polychelants and especially their paramagnetic metal, heavy metal or radioactive metal polychelates are particularly suitable for use in diagnostic imaging, heavy metal detoxification or radiotherapy. The polychelants have a linear or branched oligomeric structure comprising alternating chelant and linker moieties bound together by amide or ester moieties the carbonyl groups whereof being adjacent the chelant moieties, each polychelant comprising at least two said chelant moieties capable of complexing a metal ion.
(FR) On a mis au point des composés polychélateurs, c'est-à-dire des agents chélateurs métalliques multi-sites, ainsi que des chélates formés à l'aide de ceux-ci. Les polychélateurs et notamment leur polychélate de métal paramagnétique, de métal lourd ou de métal radioactif sont particulièrement adaptés à une utilisation en imagerie de diagnostique, en détoxification ou en radiothérapie à l'aide de métal lourd. Les polychélateurs ont une structure oligomère linéaire ou ramifiée, comprenant des fractions de chélateurs et de liaisons alternées, liées ensemble par des fractions d'amides ou d'esters, dont les groupes carbonyle sont adjacents aux fractions de chélateurs, chaque polychélateur comprenant au moins deux desdites fractions de chélateurs capables de transformer en complexe un ion de métal.
Designated States: AU, CA, FI, HU, JP, NO, SU, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
FI921805NO19921582EP0497926CA2069886AU1990066396