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1. (WO1991005761) TREATMENT OF HIV INFECTIONS AND COMPOUNDS USEFUL THEREIN
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/005761 International Application No.: PCT/US1990/005760
Publication Date: 02.05.1991 International Filing Date: 09.10.1990
Chapter 2 Demand Filed: 13.05.1991
IPC:
A61K 31/00 (2006.01) ,A61K 31/33 (2006.01) ,C07C 233/54 (2006.01) ,C07C 233/55 (2006.01) ,C07C 233/63 (2006.01) ,C07C 233/81 (2006.01) ,C07C 271/28 (2006.01) ,C07C 271/38 (2006.01) ,C07C 327/22 (2006.01) ,C07D 209/42 (2006.01) ,C07D 263/34 (2006.01) ,C07D 277/06 (2006.01) ,C07D 305/06 (2006.01) ,C07D 307/12 (2006.01) ,C07D 307/42 (2006.01) ,C07D 307/68 (2006.01) ,C07D 309/28 (2006.01) ,C07D 319/12 (2006.01) ,C07D 327/06 (2006.01) ,C07D 333/28 (2006.01) ,C07D 339/08 (2006.01) ,C07F 9/24 (2006.01) ,C07F 9/38 (2006.01) ,C07F 9/40 (2006.01) ,C07F 9/655 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
233
Carboxylic acid amides
01
having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
45
having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
53
with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
54
having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
233
Carboxylic acid amides
01
having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
45
having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
53
with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
55
having the carbon atom of the carboxamide group bound to a carbon atom of an unsaturated carbon skeleton
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
233
Carboxylic acid amides
57
having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
63
having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
233
Carboxylic acid amides
64
having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
81
having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
271
Derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
06
Esters of carbamic acids
08
having oxygen atoms of carbamate groups bound to acyclic carbon atoms
26
with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
28
to a carbon atom of a non-condensed six-membered aromatic ring
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
271
Derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
06
Esters of carbamic acids
32
having oxygen atoms of carbamate groups bound to carbon atoms of rings other than six-membered aromatic rings
38
with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
327
Thiocarboxylic acids
20
Esters of monothiocarboxylic acids
22
having carbon atoms of esterified thiocarboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
209
Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
condensed with one carbocyclic ring
04
Indoles; Hydrogenated indoles
30
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
42
Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
263
Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
02
not condensed with other rings
30
having two or three double bonds between ring members or between ring members and non-ring members
34
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
277
Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02
not condensed with other rings
04
having no double bonds between ring members or between ring members and non-ring members
06
with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
305
Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
02
not condensed with other rings
04
having no double bonds between ring members or between ring members and non-ring members
06
with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
307
Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
02
not condensed with other rings
04
having no double bonds between ring members or between ring members and non-ring members
10
with substituted hydrocarbon radicals attached to ring carbon atoms
12
Radicals substituted by oxygen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
307
Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
02
not condensed with other rings
34
having two or three double bonds between ring members or between ring members and non-ring members
38
with substituted hydrocarbon radicals attached to ring carbon atoms
40
Radicals substituted by oxygen atoms
42
Singly bound oxygen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
307
Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
02
not condensed with other rings
34
having two or three double bonds between ring members or between ring members and non-ring members
56
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
68
Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
309
Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
16
having one double bond between ring members or between a ring member and a non-ring member
28
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
319
Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
10
1,4-Dioxanes; Hydrogenated 1,4-dioxanes
12
not condensed with other rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
327
Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
02
one oxygen atom and one sulfur atom
06
Six-membered rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
333
Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
02
not condensed with other rings
04
not substituted on the ring sulfur atom
26
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
28
Halogen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
339
Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
08
Six-membered rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9
Compounds containing elements of the 5th Group of the Periodic System
02
Phosphorus compounds
06
without P-C bonds
22
Amides of acids of phosphorus
24
Esteramides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9
Compounds containing elements of the 5th Group of the Periodic System
02
Phosphorus compounds
28
with one or more P-C bonds
38
Phosphonic acids (R-P(:O)(OH)2); Thiophosphonic acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9
Compounds containing elements of the 5th Group of the Periodic System
02
Phosphorus compounds
28
with one or more P-C bonds
38
Phosphonic acids (R-P(:O)(OH)2); Thiophosphonic acids
40
Esters thereof
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9
Compounds containing elements of the 5th Group of the Periodic System
02
Phosphorus compounds
547
Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
655
having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
Applicants:
UNIROYAL CHEMICAL LTD./UNIROYAL CHEMICAL LTEE [CA/CA]; 25 Erb Street Elmira, Ontario N3B 3A3, CA
UNIROYAL CHEMICAL COMPANY, INC. [US/US]; World Headquarters Middlebury, CT 06749, US
Inventors:
HARRISON, William, A.; CA
JEWELL, Gary, E.; CA
FELAUER, Ethel, E.; CA
DEKEYSER, Mark, A.; CA
CONG, Dong, D.; CA
McGUINESS, James, A.; US
MISHRA, Anupama; CA
BROUWER, Walter, G.; CA
McPHEE, Derek, J.; CA
Agent:
SHEDDEN, John, A. ; Uniroyal Chemical Company, Inc. World Headquarters Middlebury, CT 06749, US
Priority Data:
421,15516.10.1989US
567,98215.08.1990US
588,20826.09.1990US
Title (EN) TREATMENT OF HIV INFECTIONS AND COMPOUNDS USEFUL THEREIN
(FR) TRAITEMENT D'INFECTIONS PAR HIV ET COMPOSES UTILES POUR UN TEL TRAITEMENT
Abstract:
(EN) A method of inhibiting the growth or replication of viruses of the HIV group is disclosed. Also disclosed are compounds useful in the method and pharmaceutical formulations incorporating such compounds. The method involves the use of compounds having general formula (I), wherein the substituent groups are as defined in the specification.
(FR) L'invention concerne un procédé d'inhibition de la croissance ou de la réplication de virus du groupe HIV. Sont également décrits des composés utiles dans ce procédé et des compositions pharmaceutiques contenant de tels composés. Le procédé implique l'utilisation de composés ayant la formule générale (I) dans laquelle les groupes substituants sont définis dans la demande de brevet.
Designated States: AU, BR, CA, FI, HU, JP, KR, NO, SU
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0497816RU02108785CA2067381KR1019920703049AU1990066035