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1. (WO1991005556) CAMPTOTHECIN ANALOGS AS POTENT INHIBITORS OF HUMAN COLORECTAL CANCER
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/005556 International Application No.: PCT/US1990/005986
Publication Date: 02.05.1991 International Filing Date: 23.10.1990
Chapter 2 Demand Filed: 17.05.1991
IPC:
A61K 31/47 (2006.01) ,C07D 471/04 (2006.01) ,C07D 491/14 (2006.01) ,C07D 491/20 (2006.01) ,C07D 491/22 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
491
Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
12
in which the condensed system contains three hetero rings
14
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
491
Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
12
in which the condensed system contains three hetero rings
20
Spiro-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
491
Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
22
in which the condensed system contains four or more hetero rings
Applicants:
RESEARCH TRIANGLE INSTITUTE [US/US]; Cornwallis Road Hanes Building Research Triangle Park, NC 27709, US
Inventors:
WALL, Monroe, E.; US
WANI, Mansukh; US
Agent:
OBLON, Norman, F. ; Oblon, Spivak, McClelland, Maier & Neustadt Crystal Square Five Fourth Floor 1755 South Jefferson Davis Highway Arlington, VA 22202, US
Priority Data:
424,91023.10.1989US
Not furnished22.10.1990US
Title (EN) CAMPTOTHECIN ANALOGS AS POTENT INHIBITORS OF HUMAN COLORECTAL CANCER
(FR) ANALOGUES DE CAMPTOTHECINE UTILISES COMME INHIBITEURS PUISSANTS DU CANCER COLORECTAL CHEZ L'HOMME
Abstract:
(EN) A method for synthesizing camptothecin and camptothecin analogs using a novel hydroxyl-containing tricyclic intermediate and the camptothecin analogs produced by the process. The camptothecin analogs are effective inhibitors of topoisomerase I and show anti-leukemic and anti-tumor activity.
(FR) L'invention se rapporte à un procédé de synthèse de camptothécine et d'analogues de camptothécine qui utilise un nouvel intermédiaire tricyclique contenant de l'hydroxyle, ainsi qu'aux analogues de camptothécine ainsi produits. Ces analogues de camptothécine sont des inhibiteurs efficaces de la topo-isomérase I et présentent des propriétés anti-leucémiques et anti-tumorales.
Designated States: AU, CA, FI, HU, JP, KR, SU
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0497910JPH05508619CA2067491KR1001788080000*AU1991068866