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1. (WO1991005548) SUSTAINED RELEASE COMPOSITION FOR MACROMOLECULAR PROTEINS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/005548 International Application No.: PCT/US1990/005345
Publication Date: 02.05.1991 International Filing Date: 20.09.1990
Chapter 2 Demand Filed: 15.04.1991
IPC:
A61K 9/00 (2006.01) ,A61K 9/16 (2006.01) ,A61K 9/20 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
14
Particulate form, e.g. powders
16
Agglomerates; Granulates; Microbeadlets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
Applicants:
PITMAN-MOORE, INC. [US/US]; 1401 S. Third Street P.O. Box 207 Terre Haute, IN 47808, US
Inventors:
SIVARAMAKRISHNAN, Kallidaikurichi, N.; US
GRAY, Matthew, W.; US
Agent:
FIGG, E., Anthony ; Bernard, Rothwell & Brown 1700 K Street, N.W. #800 Washington, DC 20006, US
Priority Data:
420,15610.10.1989US
Title (EN) SUSTAINED RELEASE COMPOSITION FOR MACROMOLECULAR PROTEINS
(FR) COMPOSITION A LIBERATION ENTRETENUE POUR PROTEINES MACROMOLECULAIRES
Abstract:
(EN) A sustained release composition for delivering macromolecular proteins to an animal over a prolonged period which comprises a solid wax matrix having the macromolecular protein and a water-insoluble surfactant uniformly dispersed therein is disclosed. The water-insoluble surfactant provides advantageous sustained release properties for the protein; the protein is released from the composition in amounts greater than amounts released from protein-wax compositions or from protein-wax compositions containing a water-soluble surfactant.
(FR) Composition à libération entretenue permettant d'aministrer des protéines macromoléculaires à un animal pendant une durée prolongée, comprenant une matrice en cire solide contenant la protéine moléculaire, et dans laquelle est dispersé uniformément un tensio-actif insoluble dans l'eau. Le tensio-actif insoluble dans l'eau présente des propriétés de libération entretenues avantageuses pour la protéine; ladite protéine est libérée de la composition en doses supérieures aux doses libérées par les compositions de protéine-cire ou par les compositions de protéine-cire contenant un tensio-actif soluble dans l'eau.
Designated States: AU, BB, BG, BR, CA, FI, HU, JP, KP, KR, LK, MC, MG, MW, NO, RO, SD, SU
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, IT, LU, NL, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CM, GA, ML, MR, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1990064301