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1. WO1991000916 - RECEPTORS FOR FIBROBLAST GROWTH FACTORS

Publication Number WO/1991/000916
Publication Date 24.01.1991
International Application No. PCT/US1990/003830
International Filing Date 06.07.1990
Chapter 2 Demand Filed 01.02.1991
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/71 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
71for growth factors; for growth regulators
G01N 33/74 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
74involving hormones
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/71
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
71for growth factors; for growth regulators
G01N 2333/50
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
435from animals; from humans
475Assays involving growth factors
50Fibroblast growth factors [FGF]
G01N 2333/71
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
435from animals; from humans
705Assays involving receptors, cell surface antigens or cell surface determinants
71for growth factors; for growth regulators
G01N 2500/00
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2500Screening for compounds of potential therapeutic value
G01N 33/74
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
74involving hormones ; or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
Applicants
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 300 Lakeside Drive 22nd Floor Oakland, CA 94612-3550, US (AllExceptUS)
  • WILLIAMS, Lewis, T. [US/US]; US (UsOnly)
  • JOHNSON, Daniel, E. [US/US]; US (UsOnly)
  • LEE, Pauline, E. [US/US]; US (UsOnly)
Inventors
  • WILLIAMS, Lewis, T.; US
  • JOHNSON, Daniel, E.; US
  • LEE, Pauline, E.; US
Agents
  • HESLIN, James, M.; Townsend and Townsend One Market Plaza 2000 Steuart Tower San Francisco, CA 94105, US
Priority Data
377,00306.07.1989US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) RECEPTORS FOR FIBROBLAST GROWTH FACTORS
(FR) RECEPTEURS POUR FACTEURS DE CROISSANCE DE FIBROBLASTES
Abstract
(EN)
A fibroblast growth factor (FGF) receptor including a basic fibroblast growth factor receptor has been purified. Various forms have been identified including soluble forms lacking any transmembrane segment. DNA sequences encoding full-length fibroblast growth factor receptors and polypeptides comprising a portion of an FGF-R ligand-binding domain have been isolated and sequenced. These DNAs include DNAs encoding for a basic FGF-R and a human FGF-R and are operably linked to control sequences and expressed in a culture of a compatible host transformed, transfected or electroporated by a cloning vehicle containing the DNA sequence. The invention also comprises antibodies to the receptor, methods of synthesizing the growth factor receptor proteins, methods for providing analogs of the fibroblast growth factor receptors. Methods for evaluating compositions which promote or inhibit fibroblastic growth factors and compositions which are agonistic or antagonistic to fibroblast growth factor receptors are also provided. Diagnostic and therapeutic uses are described.
(FR)
Un récepteur de facteur de croissance de fibroblaste (FGF) comprenant un récepteur de facteur de croissance de fibroblaste de base a été purifié. Diverses formes ont été identifiées y compris des formes solubles dépourvues de tout segment transmembranaire. Des séquences ADN codant des récepteurs de facteur de croissance de fibroblastes de longueur totale et des polypeptides comprenant une portion d'un domaine de liaison d'un ligand FGF-R ont été isolés et mis en séquence. Ces ADN incluent des ADN codant pour un FGF-R de base et un FGF-R humain et sont liés effectivement à des séquences de commande et sont exprimés dans une culture d'un hôte compatible transformé, transfecté ou ''électroporé'' par un véhicule de clonage contenant la séquence ADN. L'invention comprend également des anticorps contre le récepteur, des procédés de synthèse des protéines du récepteur du facteur de croissance, des procédés produisant des analogues des récepteurs du facteur de croissance de fibroblaste. Des procédés d'évaluation de compositions qui favorisent ou inhibent les facteurs de croissance de fibroblastes et des compositions qui sont agonistes ou antagonistes vis-à-vis des récepteurs de facteurs de croissance de fibroblaste sont également décrits. L'invention fait également état d'utilisations diagnostiques et thérapeutiques.
Also published as
FI920027
NO19920060
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