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1. WO1991000906 - CHIMERIC AND TRANSGENIC ANIMALS CAPABLE OF PRODUCING HUMAN ANTIBODIES

Publication Number WO/1991/000906
Publication Date 24.01.1991
International Application No. PCT/US1990/003894
International Filing Date 11.07.1990
Chapter 2 Demand Filed 12.02.1991
IPC
C07K 16/46 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
C12N 15/85 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
CPC
A01K 2207/15
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2207Modified animals
15Humanized animals
A01K 2217/00
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2217Genetically modified animals
A01K 2227/105
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2227Animals characterised by species
10Mammal
105Murine
A01K 2267/01
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2267Animals characterised by purpose
01Animal expressing industrially exogenous proteins
A01K 67/0278
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67Rearing or breeding animals, not otherwise provided for; New breeds of animals
027New breeds of vertebrates
0275Genetically modified vertebrates, e.g. transgenic
0278Humanized animals, e.g. knockin
C07K 16/462
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
461Igs containing Ig-regions, -domains or -residues form different species
462Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
Applicants
  • GENETICS INSTITUTE, INC. [US/US]; 87 CambridgePark Drive Cambridge, MA 02140, US
Inventors
  • WOOD, Clive; US
  • KAUFMAN, Randal, J.; US
  • ALT, Federick, W.; US
Agents
  • KAPINOS, Ellen, J.; Genetics Institute, Inc. Legal Affairs 87 CambridgePark Drive Cambridge, MA 02140, US
Priority Data
378,94412.07.1989US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CHIMERIC AND TRANSGENIC ANIMALS CAPABLE OF PRODUCING HUMAN ANTIBODIES
(FR) ANIMAUX CHIMERIQUES ET TRANSGENIQUES POUVANT PRODUIRE DES ANTICORPS HUMAINS
Abstract
(EN)
This invention provides a chimeric or transgenic non-human eukaryotic animal having incorporated into its germline unrearranged DNA fragments bearing exogenous immunoglobulin gene segments. This animal is capable of rearranging these segments and producing antibodies characterized by the presence of rearranged exogenous species Ig heavy chains.
(FR)
Cette invention prévoit un animal eucaryotique non humain et chimérique ou transgénique possédant des fragments d'ADN sans réarrangement incorporés à sa ligne de germes, lesdits fragments portant des segments exogènes de gènes d'immunoglobuline. Cet animal peut réarranger ces segments et produire des anticorps caractérisés par la présence de chaînes lourdes Ig d'espèces exogènes réarrangées.
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