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1. WO1991000904 - EXPRESSION OF RETROVIRUS GAG PROTEIN IN EUKARYOTIC CELLS

Publication Number WO/1991/000904
Publication Date 24.01.1991
International Application No. PCT/US1989/002415
International Filing Date 11.07.1989
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/16 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
15Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
155Lentiviridae, e.g. human immunodeficiency virus (HIV), visna-maedi virus, equine infectious anaemia virus
16HIV-1
C12N 15/85 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/005
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
C12N 15/85
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
C12N 2740/16222
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2740Reverse Transcribing RNA Viruses
00011Reverse Transcribing RNA Viruses
10011Retroviridae
16011Human Immunodeficiency Virus, HIV
16211concerning HIV gagpol
16222New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Applicants
  • SMITHKLINE BECKMAN CORPORATION [US/US]; One Franklin Plaza P.O. Box 7929 Philadelphia, PA 19101, US (AllExceptUS)
  • GHEYSEN, Dirk [BE/BE]; BE (UsOnly)
  • JACOBS, Eric [BE/BE]; BE (UsOnly)
Inventors
  • GHEYSEN, Dirk; BE
  • JACOBS, Eric; BE
Agents
  • LENTZ, Edward, T. ; SmithKline Beckman Corporation P.O. Box 7929 Philadelphia, PA 19101, US
Priority Data
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) EXPRESSION OF RETROVIRUS GAG PROTEIN IN EUKARYOTIC CELLS
(FR) EXPRESSION DE LA PROTEINE gag DE RETROVIRUS DANS DES CELLULES EUCARYOTIQUES
Abstract
(EN)
This invention is a recombinant DNA molecule for expression of HIV-1 gag precursor protein in eukaryotic cells which comprises the HIV-1 gag coding region and regulatory regions which allow for expression of the gag DNA when said DNA is used to transform eukaryotic host cells. Also described are methods for producting HIV-1 gag protein, method for producing a recombinant DNA molecule, and the HIV-1 gag protein product produced by host cells transformed with the recombinant DNA described in the instant application.
(FR)
L'invention est une molécule d'ADN de recombinaison permettant l'expression d'une protéine précurseur gag du VIH-1 dans des cellules eucaryotiques, laquelle comprend la région codante gag du VIH-1 ainsi que des régions régulatrices permettant l'expression de l'ADN de la gag lorsque l'on utilise ledit ADN pour transformer des cellules eucaryotiques hôtes. L'invention concerne également des procédés de production de la protéine gag du VIH-1, un procédé de production d'une molécule d'ADN de recombinaison, ainsi que le produit de la protéine gag du VIH-1 produit par des cellules hôtes transformées à l'aide de l'ADN de recombinaison décrit dans l'invention.
Also published as
Latest bibliographic data on file with the International Bureau