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1. WO1991000872 - MONOCLONAL ANTIBODIES TO C-REACTIVE PROTEIN

Publication Number WO/1991/000872
Publication Date 24.01.1991
International Application No. PCT/US1990/003487
International Filing Date 20.06.1990
Chapter 2 Demand Filed 08.01.1991
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/52 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
C07K 16/18 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/52
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
C07K 16/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
Applicants
  • RUSH-PRESBYTERIAN-ST. LUKE'S MEDICAL CENTRE [US/US]; 1653 West Congress Parkway Chicago, IL 60612, US
Inventors
  • SIEGEL, Joan, N.; US
  • POTEMPA, Lawrence, A.; US
  • GEWURZ, Henry; US
Agents
  • CROOK, Wannell, M.; Willian, Brinks, Olds, Hofer, Gilson & Lione NBC Tower, Suite 3600 455 North Cityfront Plaza Drive Chicago, IL 60611, US
Priority Data
372,44227.06.1989US
374,16629.06.1989US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MONOCLONAL ANTIBODIES TO C-REACTIVE PROTEIN
(FR) ANITCORPS MONOCLONAUX CONTRE LA PROTEINE REACTIVE C
Abstract
(EN)
The present invention comprises monoclonal antibodies reactive with native C-reactive protein (CRP) and modified CRP having the specificities described herein. The invention also comprises the hybridomas used to produce these antibodies. Monoclonal antibody 3H12 is used to show inhibition binding and a lack of inhibition binding by use of peptides. The claimed antibodies may be used to detect or quantitate native CRP and modified CRP, and kits for performing such assays are part of the invention.
(FR)
L'invention concerne des anticorps monoclonaux réagissant avec la protéine réactive C (PRC) native et la PRC modifiée dont les spécificités sont décrites dans l'invention. L'invention concerne également les hybridomes utilisés pour produire ces anticorps. On utilise l'anticorps monoclonal 3H12 afin d'illustrer la liaison d'inhibition ainsi qu'une absence de liaison d'inhibition à l'aide de peptides. On peut utiliser les anticorps de l'invention afin de détecter ou de quantifier la PRC native et la PRC modifiée, des kits permettant de procéder à ces analyses font partie de l'invention.
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