Processing

Please wait...

Settings

Settings

1. WO1991000869 - SUBSTITUTION ANALOGUES OF MAGAININ PEPTIDES

Publication Number WO/1991/000869
Publication Date 24.01.1991
International Application No. PCT/US1990/003675
International Filing Date 28.06.1990
Chapter 2 Demand Filed 05.02.1991
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/46 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 13/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
02of urine or of the urinary tract, e.g. urine acidifiers
A61P 15/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
C07K 14/46
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
Y02A 50/473
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
50in human health protection
30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
46Medical treatment of waterborne diseases characterized by the agent
468The waterborne disease being caused by a bacteria
473the bacteria being Escherichia coli, i.e. E. coli Infection
Applicants
  • SCRIPPS CLINIC AND RESEARCH FOUNDATION [US/US]; 1066 North Torrey Pines Road La Jolla, CA 92037, US
Inventors
  • HOUGHTEN, Richard, A.; US
  • CUERVO, Julio, H.; US
Agents
  • GAMSON, Edward, P.; Dressler, Goldsmith, Shore, Sutker & Milnamow Two Prudential Plaza, Suite 4700 180 North Stetson Avenue Chicago, IL 60601-6707, US
Priority Data
376,75407.07.1989US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SUBSTITUTION ANALOGUES OF MAGAININ PEPTIDES
(FR) ANALOGUES DE SUBSTITUTION DES PEPTIDES DE LA MAGAININE
Abstract
(EN)
A compound comprising a Magainin I or Magainin II peptide wherein at least one substitution may be made for certain amino acid residues with other amino acid residues, said peptides known as substitution analogues. In addition to such substitutions, there may be included within the scope of the invention analogues wherein at least one of amino acid residues 15 and 23 may have been deleted as well, and wherein substitutions were made in the remaining peptide chain. Certain substitution analogues within the scope of the present invention have been shown to possess increased biological activity.
(FR)
Dans un composé comprenant un peptide de magainine I ou magainine II, il est possible d'effectuer au moins une substitution de certains résidus d'acides aminés par d'autres résidus d'acides aminés, lesdits peptides étant connus en tant qu'analogues de substitution. Outre ces substitutions, il est possible d'inclure dans le cadre de cette invention, des analogues dans lesquels au moins l'un des résidus d'acides aminés 15 et 23 peut avoir été supprimé également, et où des substitutions ont été effectuées dans la chaîne de peptides restants. Certains analogues de substitution dans le cadre de cette invention se sont révélés avoir une activité biologique plus intense.
Also published as
Latest bibliographic data on file with the International Bureau