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1. WO1991000853 - USE OF POLYAMINES AS IONIC-CHANNEL REGULATING AGENTS

Publication Number WO/1991/000853
Publication Date 24.01.1991
International Application No. PCT/US1990/003771
International Filing Date 03.07.1990
Chapter 2 Demand Filed 01.02.1991
IPC
A61K 31/13 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines, e.g. amantadine
A61K 31/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
C07C 211/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
211Compounds containing amino groups bound to a carbon skeleton
01having amino groups bound to acyclic carbon atoms
02of an acyclic saturated carbon skeleton
14Amines containing amino groups bound to at least two aminoalkyl groups, e.g. diethylenetriamines
C07C 237/10 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
237Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
02having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
04the carbon skeleton being acyclic and saturated
10having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
C07C 239/16 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
239Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
08Hydroxylamino compounds or their ethers or esters
16having nitrogen atoms of hydroxylamino groups further bound to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
C07C 279/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
279Derivatives of guanidine, i.e. compounds containing the group the singly-bound nitrogen atoms not being part of nitro or nitroso groups
04having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
12being further substituted by nitrogen atoms not being part of nitro or nitroso groups
CPC
A61K 31/13
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines
A61K 31/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
C07C 211/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
211Compounds containing amino groups bound to a carbon skeleton
01having amino groups bound to acyclic carbon atoms
02of an acyclic saturated carbon skeleton
14Amines containing amino groups bound to at least two aminoalkyl groups, e.g. diethylenetriamines
C07C 237/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
237Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
02having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
04the carbon skeleton being acyclic and saturated
10having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
C07C 239/16
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
239Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
08Hydroxylamino compounds or their ethers or esters
16having nitrogen atoms of hydroxylamino groups further bound to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
C07C 279/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
279Derivatives of guanidine, i.e. compounds containing the group , the singly-bound nitrogen atoms not being part of nitro or nitroso groups
04having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
12being further substituted by nitrogen atoms not being part of nitro or nitroso groups
Applicants
  • NEW YORK UNIVERSITY [US/US]; Office of Industrial Liaison 550 First Avenue New York, NY 10016, US (AllExceptUS)
  • CHERKSEY, Bruce, D. [US/US]; US (UsOnly)
  • LLINAS, Rodolfo, R. [US/US]; US (UsOnly)
  • SUGIMORI, Mutsuyuki [JP/US]; US (UsOnly)
Inventors
  • CHERKSEY, Bruce, D.; US
  • LLINAS, Rodolfo, R.; US
  • SUGIMORI, Mutsuyuki; US
Agents
  • GOGORIS, Adda, C. ; Darby & Darby 805 Third Avenue New York, NY 10022, US
Priority Data
375,77603.07.1989US
427,33326.10.1989US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) USE OF POLYAMINES AS IONIC-CHANNEL REGULATING AGENTS
(FR) EMPLOI DE POLYAMINES EN TANT QU'AGENTS REGULATEURS DE CANAUX IONIQUES
Abstract
(EN)
Polyamine compounds are used as agents regulating ionic conductances in cellular membranes. These polyamines are used in blocking, modulating or activating calcium and other cationic channels in neuronal cell membranes and in blocking, modulating or activating calcium channels of a specific type in any cell membrane when such channels are present.
(FR)
On utilise des composés de polyamine en tant qu'agents régulateurs de conductances ioniques dans des membranes cellulaires. On utilise ces polyamines pour bloquer, moduler ou activer les canaux calciques ainsi que d'autres canaux cationiques se trouvant dans des membranes cellulaires neuronales, et pour bloquer, moduler ou activer les canaux calciques d'un type spécifique dans n'importe quelle membrane cellulaire lorsque de tels canaux sont présents.
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