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1. WO1991000733 - METHOD OF TREATMENT OF ANDROGEN-RELATED DISEASES

Publication Number WO/1991/000733
Publication Date 24.01.1991
International Application No. PCT/CA1990/000212
International Filing Date 05.07.1990
Chapter 2 Demand Filed 01.02.1991
IPC
A61K 31/565 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopentahydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
565not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol
A61K 31/57 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopentahydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
57substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, progesterone
A61K 31/575 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopentahydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
575substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
CPC
A61K 31/565
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
565not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
A61K 31/57
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
57substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, progesterone
A61K 31/575
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
575substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
Y02A 50/395
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
50in human health protection
30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
38Medical treatment of vector-borne diseases characterised by the agent
381the vector-borne disease being caused by a virus
384of the genus Flavivirus
395the disease being Tick-borne encephalitis [TBE]
Y10S 514/80
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10TECHNICAL SUBJECTS COVERED BY FORMER USPC
STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
514Drug, bio-affecting and body treating compositions
80LHRH like
Applicants
  • ENDORECHERCHE INC. [CA/CA]; 2989 de la Promenage Ste-Foy Quebec G1W 2J6, CA
Inventors
  • LABRIE, Fernand; CA
Agents
  • MITCHELL, Richard, J.; Marks & Clerk 50 O'Connor Street, Third Floor P.O. Box 957, Station B Ottawa, Ontario K1P 5S7, CA
Priority Data
376,71007.07.1989US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD OF TREATMENT OF ANDROGEN-RELATED DISEASES
(FR) PROCEDE DE TRAITEMENT DES MALADIES ASSOCIEES AUX ANDROGENES
Abstract
(EN)
A method of treatment of androgen-related diseases such as prostate cancer in susceptible male animals, including humans, comprises administering novel antiandrogens and/or novel sex steroid biosynthesis inhibitors as part of a combination therapy. Sex steroid biosynthesis inhibitors, especially those capable of inhibiting conversion of dehydroepiandrosterone (DHEA) or 4-androstenedione ($g(D)4-dione) to natural sex steroida (and testosterone into dihydrotestosterone) in peripheral tissues, are used in combination with antiandrogens usually after blockade of testicular hormonal secretions. Antiestrogens can also be part of the combination therapy. Pharmaceutical compositions and two, three, four and five component kits are useful for such combination treatment.
(FR)
Le procédé décrit, qui sert à traiter les maladies associées aux androgènes, tels que les cancers de la prostate, chez des animaux mâles susceptibles de développer de telles pathologies, y compris chez l'homme, consiste à procéder à l'administration de nouveaux anti-androgènes et/ou de nouveaux inhibiteurs de biosynthèse des stéroïdes sexuels, cette administration faisant partie d'une thérapie combinée. Les inhibiteurs de biosynthèse des stéroïdes sexuels, tels qu'en particulier ceux qui sont capables d'inhiber la conversion de déhydroépiandrostéronea (DHEA) ou de 4-androsténedione ($g(D)4-dione) en stéroïdes sexuels naturels (et de testostérone en dihydrotestostérone) dans les tissus périphériques, sont utilisés en combinaison avec des anti-androgènes, habituellement après blocage des sécrétions hormonales testiculaires. L'administration d'anti-÷strogènes peut également faire partie de la thérapie combinée. Des compositions pharmaceutiques et deux, trois, quatre et cinq kits d'éléments utiles dans un tel traitement combiné sont décrits.
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