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1. WO1991000727 - SUBSTITUTED 2-AMINOTETRALINS

Publication Number WO/1991/000727
Publication Date 24.01.1991
International Application No. PCT/US1990/003761
International Filing Date 02.07.1990
Chapter 2 Demand Filed 31.01.1991
IPC
C07C 215/64 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
215Compounds containing amino and hydroxy groups bound to the same carbon skeleton
46having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
64with rings other than six-membered aromatic rings being part of the carbon skeleton
C07C 217/16 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
217Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
02having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
04the carbon skeleton being acyclic and saturated
06having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
14the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
16the six-membered aromatic ring or condensed ring system containing that ring not being further substituted
C07C 217/74 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
217Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
54having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
74with rings other than six-membered aromatic rings being part of the carbon skeleton
C07D 307/88 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
307Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
77ortho- or peri-condensed with carbocyclic rings or ring systems
87Benzo furans; Hydrogenated benzo furans
88with one oxygen atom directly attached in position 1 or 3
CPC
C07C 215/64
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
215Compounds containing amino and hydroxy groups bound to the same carbon skeleton
46having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
64with rings other than six-membered aromatic rings being part of the carbon skeleton
C07C 217/16
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
217Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
02having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
04the carbon skeleton being acyclic and saturated
06having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
14the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
16the six-membered aromatic ring or condensed ring system containing that ring not being further substituted
C07C 217/74
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
217Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
54having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
74with rings other than six-membered aromatic rings being part of the carbon skeleton
C07C 2602/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
2602Systems containing two condensed rings
02the rings having only two atoms in common
04One of the condensed rings being a six-membered aromatic ring
08the other ring being five-membered, e.g. indane
C07C 2602/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
2602Systems containing two condensed rings
02the rings having only two atoms in common
04One of the condensed rings being a six-membered aromatic ring
10the other ring being six-membered, e.g. tetraline
C07D 307/88
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
307Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
77ortho- or peri-condensed with carbocyclic rings or ring systems
87Benzo [c] furans; Hydrogenated benzo [c] furans
88with one oxygen atom directly attached in position 1 or 3
Applicants
  • WHITBY RESEARCH, INC. [US/US]; 1001 Health Sciences Road West Irvine, CA 92715, US
Inventors
  • PECK, James, V.; US
  • MINASKANIAN, Gevork; US
Agents
  • BARAN, Robert, J. ; Whitby Research, Inc. 1001 Health Sciences Road West Irvine, CA 92715, US
  • HACKLER, Walter, A.; 2372 S.E. Bristol Ste. B Santa Ana Heights, CA 92707, US
Priority Data
375,58305.07.1989US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SUBSTITUTED 2-AMINOTETRALINS
(FR) 2-AMINOTETRALINES SUBSTITUEES
Abstract
(EN)
Optically active or racemic compounds are provided having formula (I). Wherein the radicals R1, R2, R3, R4, R6, X and N are defined in the specification. These compounds are optically active or racemic mixtures capable of binding selectively one or more dopamine D2 receptors, for instance in humans. They are useful in treatment of disorders of the central nervous, cardiovascular, and endocrine systems such as elevated intraocular pressure, schizophrenia and parkinsonism, and for inducing anorexia and weight loss in humans and other mammals.
(FR)
Composés optiquement actifs ou des racémates dont la formule est (I), où les radicaux R1, R2, R3, R4, R6, X et N ont la notation donnée dans la description. Ces composés sont des mélanges optiquement actifs ou racémiques pouvant sélectivement lier un ou plusieurs récepteurs de dopamine D2, par exemple chez l'être humain. Ils sont utiles dans le traitement des troubles des systèmes nerveux central, cardio-vasculaire, et endocrinien tels que la pression intraoculaire élevée, les schizophrénies et le parkinsonisme, et pour provoquer l'anorexie et l'amaigrissement chez les êtres humains et d'autres mammifères.
Also published as
Latest bibliographic data on file with the International Bureau